Externally controlled drug release using a gold nanorod contained composite membrane
Externally controlled drug release using a gold nanorod contained composite membrane
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DOI：
10.1039/c6nr00362a
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发表时间：
2016-01-01
期刊：
影响因子：
6.7
通讯作者：
Park, Myoung-Hwan
中科院分区：
文献类型：
--
作者：
Kim, Kibeom;Jo, Min-Chul;Park, Myoung-Hwan
使用由金纳米棒和树枝状聚合物组成的纳米多孔膜的多功能药物递送装置已被证明从含有高度富集的治疗剂的储库提供光触发的按需脉冲释放，以满足真实的患者的需要。在静态和流体装置中，药物释放速率与近红外激光的温度升高和照射能量直接相关。通过体外实验进一步证实了这种用于按需控制的生物相容性平台。有趣的是，在不存在和存在NIR光的情况下，从每种药物获得对刺激的不同反应，这表明我们的按需药物递送系统在需要多药物递送策略的微创治疗中的通用潜力。增强的递送系统将通过调节血浆药物分布来提高治疗功效并减少副作用。
Versatile drug delivery devices using nanoporous membranes consisting of gold nanorods and dendrimers have been demonstrated to provide light-triggered on-demand pulsatile release from a reservoir containing highly enriched therapeutics for a real patient's needs. The drug release rate is directly correlated with the temperature increase and irradiated energy of a near-IR laser in both static and fluidic devices. This biocompatible platform for on-demand control was further confirmed by in vitro experiments. Interestingly, different responses to stimuli were obtained from each drug in the absence and presence of NIR light, indicating the versatile potential of our on-demand drug delivery system in less-invasive therapies requiring multi-drug delivery strategies. The enhanced delivery system will improve therapeutic efficacy and reduce side effects through regulation of plasma drug profiles.