Composition-Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy
Composition-Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy
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DOI：
10.1002/adma.202203734
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发表时间：
2022-07-03
影响因子：
29.4
通讯作者：
Zang, Shuang-Quan
中科院分区：
文献类型：
--
作者：
Hua, Yue;Huang, Jia-Hong;Zang, Shuang-Quan
合金化是调整金属团簇性质的有效化学方法。作为一类有前途的放射增敏剂，以往报道的大多数金属簇具有单一的功能，不能克服乏氧肿瘤的放射抗性。本文合成了具有明亮发光和良好生物相容性的原子级精确合金团簇Pt 2 M4（M = Au，Ag，Cu），并探讨了其组成依赖的仿酶活性和放射增敏效应。具体而言，只有Pt 2Au 4簇显示过氧化氢酶样活性，而其他的不具有clusterzyme属性，其放射增敏效果是最高的所有合金簇测试。通过利用内源性H2 O2的分解可持续产生O-2，Pt 2Au 4簇调节肿瘤缺氧并提高放射治疗的疗效。因此，这项工作推进了簇合金化策略，以产生用于改善缺氧肿瘤治疗的多功能治疗剂。
Alloying is an efficient chemistry to tailor the properties of metal clusters. As a class of promising radiosensitizers, most previously reported metal clusters exhibit unitary function and cannot overcome radioresistance of hypoxic tumors. Here, atomically precise alloy clusters Pt2M4 (M = Au, Ag, Cu) are synthesized with bright luminescence and adequate biocompatibility, and their composition-dependent enzyme mimicking activity and radiosensitizing effect is explored. Specifically, only the Pt2Au4 cluster displays catalase-like activity, while the others do not have clusterzyme properties, and its radiosensitizing effect is the highest among all the alloy clusters tested. By taking advantage of the sustainable production of O-2 via the decomposition of endogenous H2O2, the Pt2Au4 cluster modulates tumor hypoxia as well as increases the efficacy of radiotherapy. This work thus advances the cluster alloying strategy to produce multifunctional therapeutic agents for improving hypoxic tumor therapy.