The role of CA3 hippocampal NMDA receptors in paired associate learning
The role of CA3 hippocampal NMDA receptors in paired associate learning
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DOI：
10.1523/jneurosci.4194-05.2006
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发表时间：
2006-01-18
影响因子：
5.3
通讯作者：
Greene, R
中科院分区：
文献类型：
--
作者：
Rajji, T;Chapman, D;Greene, R
海马体对于人类的陈述性记忆和啮齿动物的情景记忆是必需的。目前相当多的研究集中在海马体特定亚区域内可塑性的作用。在这里，使用病毒载体暂时控制局灶性缺失的NR1基因，我们表明，学习新的特定线索和他们的上下文之间的配对协会是依赖于CA3 NMDA受体。在< 30%的背侧海马体中缺失CA3 NR1基因足以破坏新的学习，而相同的治疗不会阻止先前获得的配对联想的表达，并且不会影响辨别环境或配对联想学习的能力，当线索或环境熟悉时。研究结果表明，CA3 NMDA受体特别支持编码的新经验，涉及偶然和偶然的协会。
The hippocampus is necessary for declarative memory in humans and episodic memory in rodents. Considerable current research is focused on the role of plasticity within specific subfields of the hippocampus. Here, using a viral vector to temporally control a focal deletion of the NR1 gene, we show that learning novel paired associations between specific cues and their context is dependent on CA3 NMDA receptors. Deletion of CA3 NR1 genes in < 30% of the dorsal hippocampus was sufficient to disrupt new learning, whereas the same treatment does not prevent expression of previously acquired paired associates and does not affect the ability to discriminate contexts or paired associate learning when either the cues or the context is familiar. The findings suggest that CA3 NMDA receptors specifically support the encoding of new experiences to involve incidental and contingent associations.