Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model
Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model
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DOI：
10.1161/01.cir.98.19.2055
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发表时间：
1998-11-10
期刊：
影响因子：
37.8
通讯作者：
Ben-Haim, SA
中科院分区：
文献类型：
--
作者：
Gepstein, L;Goldin, A;Ben-Haim, SA
背景-定义功能障碍心肌组织的存在、程度和性质仍然是诊断心脏病学的基石。使用一种非透视、基于导管的绘图技术，可以在空间上关联心内膜机械和电气数据，用于量化犬慢性梗塞模型中的机电变化。方法和结果 - 我们绘制了 11 只慢性梗塞犬（LAD 结扎后 4 周）和 6 只对照犬的左心室 (LV) 机电区域特性。通过在整个心动周期中多个心内膜部位对特殊导管的位置进行采样，并同时记录导管尖端的局部电图，重建了左心室的动态 3 维机电图。平均心内膜局部缩短（LS，在收缩末期测量并标准化为舒张末期）和心内双极电图振幅在 13 个 LV 区域进行量化。梗塞区域的心内膜 LS 显着较低（1.2+/-0.9% [平均值+/-SEM]，P
Background-Defining the presence, extent, and nature of the dysfunctional myocardial tissue remains a cornerstone in diagnostic cardiology. A nonfluoroscopic, catheter-based mapping technique that can spatially associate endocardial mechanical and electrical data was used to quantify electromechanical changes in the canine chronic infarction model.Methods and Results-We mapped the left ventricular (LV) electromechanical regional properties in 11 dogs with chronic infarction (4 weeks after LAD ligation) and 6 controls. By sampling the location of a special catheter throughout the cardiac cycle at multiple endocardial sites and simultaneously recording local electrograms from the catheter tip, the dynamic 3-dimensional electromechanical map of the LV was reconstructed. Average endocardial local shortening (LS, measured at end systole and normalized to end diastole) and intracardiac bipolar electrogram amplitude were quantified at 13 LV regions. Endocardial LS was significantly lower at the infarcted area (1.2+/-0.9% [mean+/-SEM], P