Blood lipid and lipoprotein levels and the risk of cancer of the colon and rectum - A prospective study of 62,173 Norwegian men and women
Blood lipid and lipoprotein levels and the risk of cancer of the colon and rectum - A prospective study of 62,173 Norwegian men and women
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DOI：
10.3109/00365529709000187
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发表时间：
1997-02-01
影响因子：
1.9
通讯作者：
Urdal, P
中科院分区：
文献类型：
--
作者：
Gaard, M;Tretli, S;Urdal, P
背景：低血清总胆固醇水平虽然有益于心血管疾病，但可能增加患癌症的风险，这引起了人们的关注。这项前瞻性队列研究分析了以下假设：低血清总胆固醇水平或其亚组分(血清低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯)会增加患结肠癌和直肠癌的风险。方法：1977至1983年间，62,173名男性和女性参加了挪威国家健康筛查局进行的健康筛查。筛查包括问卷调查、人体测量和非空腹血液样本的分析，包括血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯。结果：在7至13年的随访中，通过与挪威癌症登记中心的联系，186名患者被发现患有结肠癌，106名患者患有直肠癌。在男性中，血脂和脂蛋白水平与近端结肠、远端结肠或直肠的癌症风险之间没有相关性。在女性中，总胆固醇和低密度脂蛋白胆固醇水平与远端结肠癌的风险呈正式的统计学显著负相关，总胆固醇水平与直肠癌呈正相关趋势。结论：在女性中有统计学意义的结果被解释为偶然性的，我们得出结论，血脂和脂蛋白水平与该队列中男性或女性患结肠癌或直肠癌的风险无关。
Background: Concern has been raised that a low total serum cholesterol level, although beneficial for cardiovascular diseases, may increase the risk of cancer. This prospective cohort study analyses the hypotheses that a low total serum cholesterol level or its subfractions (serum low-density-lipoprotein cholesterol, high-density-lipoprotein cholesterol, and triglycerides) increase the risk of cancer of the colon and rectum. Methods: Between 1977 and 1983, 62,173 men and women attended a health screening carried out by the Norwegian National Health Screening Service. The screening consisted of a questionnaire, anthropometric measurements, and samples of non-fasting blood drawn far analyses of serum total cholesterol, low-density-lipoprotein cholesterol, high-density-lipoprotein cholesterol, and triglycerides. Results: During the 7- to 13-year follow-up, 186 patients were found to have colon cancer and 106 rectal cancer by linkage to the Norwegian Cancer Registry. Among men there were no associations between blood lipid and lipoprotein levels and risk of cancer of the proximal colon, distal colon, or the rectum. Among women there was a formal statistically significant inverse relationship between level of total cholesterol and low-density-lipoprotein cholesterol and risk of distal colon cancer, and a positive trend between total cholesterol level and rectal cancer. Conclusions: The statistically significant results among women were interpreted as incidental, and we conclude that blood lipid and lipoprotein levels were not associated with the risk of colon or rectum cancer in men or women in this cohort.