Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
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DOI：
10.1158/1940-6207.capr-14-0143
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发表时间：
2014-11-01
影响因子：
3.3
通讯作者：
Johanning, Gary L.
中科院分区：
文献类型：
--
作者：
Piyathilake, Chandrika J.;Macaluso, Maurizio;Johanning, Gary L.
我们以前报道过，人乳头瘤病毒（HPV）16启动子（31、37、43、52和58位）和增强子7862位CpG位点的甲基化程度越高，诊断为HPV 16相关CIN 2+的可能性越低。本研究的目的是复制我们以前的研究结果，并评估叶酸和维生素B12的血浆浓度对HPV 16甲基化程度（HPV 16 m）的影响。该研究包括315名HPV 16阳性的女性，诊断为CIN 2+或
We previously reported that a higher degree of methylation of CpG sites in the promoter (positions 31, 37, 43, 52, and 58) and enhancer site 7862 of human papillomavirus (HPV) 16 was associated with a lower likelihood of being diagnosed with HPV 16-associated CIN 2+. The purpose of this study was to replicate our previous findings and, in addition, to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV 16 methylation (HPV 16m). The study included 315 HPV 16-positive women diagnosed with either CIN 2+ or