The prevalence, morbidities, and treatments of insomnia.
The prevalence, morbidities, and treatments of insomnia.
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失眠的患病率、发病率和治疗方法。
DOI：
10.2174/187152707779940754
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
G. Zammit
中科院分区：
文献类型：
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作者：
G. Zammit
失眠是一种常见病，通常与其他疾病同时发病。它与显着的发病率相关，包括夜间困扰、认知功能受损、白天功能受损以及事故风险增加。失眠患者比没有失眠的人更频繁地使用医疗服务，而且他们出现某些健康问题的风险更大；最明显的是抑郁症等精神疾病。现在已知失眠的严重影响需要诊断和治疗。行为和精神药物治疗已经存在一段时间了。然而，以前常见的治疗药物如巴比妥类药物和苯二氮卓类药物已被新的 GABA(A) 受体变构调节剂和其他具有新作用机制的治疗药物所取代。本文介绍了现有的失眠治疗方法，并回顾了正在开发的失眠新疗法、治疗目标和治疗方法，这些可能为从业者和患者带来希望。
Insomnia is a common condition that often is co-morbid with other illnesses. It is associated with significant morbidities, including nighttime distress, impaired cognitive functioning, impaired daytime functioning, and increased risk of accidents. People with insomnia utilize healthcare services more often than those without insomnia, and they are at greater risk for the development of certain health problems; most notably psychiatric illness such as depression. It is now known that the significant impact of insomnia warrants diagnosis and treatment. Behavioral and psychopharmacological treatments have been available for some time. However, formerly common classes of therapeutics such as the barbiturates and benzodiazepines have been replaced by new allosteric modulators of the GABA(A) receptor and other therapeutics with novel mechanisms of action. This article presents existing approaches to insomnia treatment, and reviews new treatments, therapeutic targets, and treatment approaches to insomnia under development that may offer promise to practitioners and patients.