Nerve injury induces plasticity that results in spinal inhibitory effects of galanin
Nerve injury induces plasticity that results in spinal inhibitory effects of galanin
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DOI：
10.1016/s0304-3959(02)00180-x
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发表时间：
2002-08-01
期刊：
影响因子：
7.4
通讯作者：
Dickenson, AH
中科院分区：
文献类型：
--
作者：
Flatters, SJL;Fox, AJ;Dickenson, AH
甘丙肽是一种由29个氨基酸组成的神经肽，与伤害感受过程有关。本研究探讨了外源性甘丙肽对脊髓神经结扎（SNL）神经病理性疼痛模型中脊髓背角神经元活性的影响。SNL大鼠，但不是幼稚或假手术大鼠表现出异常性疼痛的行为指示，在麻醉大鼠，细胞外记录从个别会聚背角神经元刺激后，外周感受野电或自然（无害的机械，有害的机械和有害的热）刺激。甘丙肽（0.5-50 μ g）的脊髓给药引起幼稚大鼠中对自然和电刺激的神经元反应的轻微促进，并且在50 μ g甘丙肽后的假手术大鼠中神经元反应的抑制高达65%。相反，在SNL大鼠中，在脊髓甘丙肽给药后，对自然刺激和电刺激的反应有高达80%的显著抑制。这些结果表明，在周围神经损伤后，在脊髓水平的甘丙肽和/或其受体的水平存在可塑性，使得外源性甘丙肽的作用有利于抑制功能。(C)2002年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
Galanin is a 29-amino-acid neuropeptide that has been implicated in the processes of nociception. This study examines the effect of exogenous galanin on dorsal horn neurone activity in vivo in the spinal nerve ligation (SNL) model of neuropathic pain. SNL rats but not naive or sham-operated rats exhibited behaviour indicative of allodynia, In anaesthetized rats, extracellular recordings were made from individual convergent dorsal horn neurones following stimulation of peripheral receptive fields electrically or with natural (innocuous mechanical, noxious mechanical and noxious thermal) stimuli. Spinal administration of galanin (0.5-50 mug) caused a slight facilitation of the neuronal responses to natural and electrical stimuli in naive rats and up to a 65% inhibition of neuronal responses in sham-operated rats following 50 mug galanin. In contrast, there was a marked inhibition of up to 80% of responses to both natural and electrical stimuli in SNL rats following spinal galanin administration, These results suggest that following peripheral nerve injury, there is plasticity in the levels of galanin and/or its receptors at spinal cord level so that the effect of exogenous galanin favours inhibitory function. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.