Effects of Glucocorticoids in the Immune System
Effects of Glucocorticoids in the Immune System
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DOI：
10.1007/978-1-4939-2895-8_9
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Cato, Andrew C. B.
中科院分区：
文献类型：
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作者：
Oppong, Emmanuel;Cato, Andrew C. B.
糖皮质激素（GC）是具有广泛影响的类固醇激素。它们通过刺激肝脏中的脂肪生成来控制中间代谢，从肝外组织中动员氨基酸，抑制肌肉和脂肪组织中的葡萄糖摄取，并刺激脂肪组织中的脂肪分解。它们还介导压力反应。它们发挥有效的免疫抑制和抗炎作用，特别是在连续给药时。了解糖皮质激素的这些不同作用需要详细了解其作用模式。多年来的研究已经揭示了这种激素的分子作用的一些细节，特别是在免疫细胞中。在这一章中，我们总结了最新的发现，糖皮质激素在免疫细胞中的作用，以确定重要的控制点，可能是相关的糖皮质激素治疗。
Glucocorticoids (GCs) are steroid hormones with widespread effects. They control intermediate metabolism by stimulating gluconeogenesis in the liver, mobilize amino acids from extra hepatic tissues, inhibit glucose uptake in muscle and adipose tissue, and stimulate fat breakdown in adipose tissue. They also mediate stress response. They exert potent immune-suppressive and anti-inflammatory effects particularly when administered pharmacologically. Understanding these diverse effects of glucocorticoids requires a detailed knowledge of their mode of action. Research over the years has uncovered several details on the molecular action of this hormone, especially in immune cells. In this chapter, we have summarized the latest findings on the action of glucocorticoids in immune cells with a view of identifying important control points that may be relevant in glucocorticoid therapy.