Effects of allopurinol on the therapeutic efficacy of methotrexate.
Effects of allopurinol on the therapeutic efficacy of methotrexate.
复制标题
别嘌呤醇对甲氨蝶呤治疗效果的影响。
作者：
G. Grindey;R. Moran
甲氨蝶呤对早期白血病L1210的抗肿瘤作用被部分逆转的共同管理别嘌呤醇在体内，即使别嘌呤醇没有改变甲氨蝶呤对L1210细胞的生长抑制作用在文化。这些数据表明，这种抗肿瘤活性的改变是由于别嘌呤醇（一种有效的黄嘌呤氧化酶抑制剂）对预先形成的全身嘌呤的催化作用降低所致。另一方面，甲氨蝶呤对P288白血病的治疗效果没有显著改变，别嘌呤醇没有显著改变甲氨蝶呤的毒性，在小鼠中，甲氨蝶呤的抗白血病作用与无嘌呤死亡而不是无胸腺嘧啶死亡更相关。
The antitumor effects of methotrexate against early leukemia L1210 were partially reversed by the coadministration of allopurinol in vivo, even though allopurinol did not alter the growth-inhibitory effects of methotrexate against L1210 cells in culture. These data suggest that this alteration in antitumor activity results from a decreased catabolism of preformed systemic purines by allopurinol, a potent inhibitor of xanthine oxidase. On the other hand, the therapeutic effect of methotrexate against the P288 leukemia was not significantly altered by allopurinol did not significantly alter the toxicity of methotrexate that, in the mouse, the antileukemic effects of methotrexate are more related to a purineless rather than a thymineless death.