Diversification of dendritic cell subsets: Emerging roles for STAT proteins.
Diversification of dendritic cell subsets: Emerging roles for STAT proteins.
复制标题
DOI：
10.4161/jkst.25112
复制
发表时间：
2013-10-01
期刊：
影响因子：
--
通讯作者：
Watowich SS
中科院分区：
文献类型：
--
作者：
Li HS;Watowich SS
术语树突状细胞（DC）是指在免疫中具有关键作用的造血细胞群体，包括响应病原体引起的危险信号的免疫活化和免疫耐受。异常的DC活性是自身免疫的一个重要因素，而严重的DC耗竭伴随着某些免疫缺陷疾病。相比之下，DC已成为在免疫治疗中操纵的有吸引力的候选者。最近的研究表明，STAT转录因子在DC中具有独特的作用，这一特征可能在未来的基于DC的治疗中被利用。在这里，我们专注于STAT1，STAT3和STAT5在DC生成和DC介导的免疫反应中的功能。
The term dendritic cell (DC) refers to a population of hematopoietic cells with critical roles in immunity, including immune activation in response to pathogen-elicited danger signals and immune tolerance. Aberrant DC activity is an important contributing factor in autoimmunity, while severe DC depletion accompanies certain immunodeficiency conditions. By contrast, DCs have become attractive candidates to manipulate in immune therapy. Recent studies show that STAT transcription factors have unique roles in DCs, a feature that might be exploited in future DC-based therapies. Here, we focus on the functions of STAT1, STAT3, and STAT5 in DC generation and DC-mediated immune responses.