Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity.
Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity.
复制标题
甲状腺功能亢进症和甲状腺功能减退症产生的肉毒碱棕榈酰转移酶-I mRNA 丰度的变化与活性的变化平行。
DOI：
10.1006/bbrc.1994.1791
复制
发表时间：
1994
影响因子：
3.1
通讯作者：
Cook,GA
中科院分区：
文献类型：
--
作者：
Mynatt,RL;Park,EA;Thorngate,FE;Das,HK;Cook,GA
To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.
