POSSIBLE INVOLVEMENT OF SUPERSENSITIVITY IN CEREBRAL BETA-ADRENERGIC AND DOPAMINERGIC RECEPTORS IN THE OCCURRENCE OF SENSITIZATION TO D-METHAMPHETAMINE IN MICE
POSSIBLE INVOLVEMENT OF SUPERSENSITIVITY IN CEREBRAL BETA-ADRENERGIC AND DOPAMINERGIC RECEPTORS IN THE OCCURRENCE OF SENSITIZATION TO D-METHAMPHETAMINE IN MICE
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DOI：
10.1016/0197-0186(90)90119-e
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发表时间：
1990-01-01
影响因子：
4.2
通讯作者：
KURIYAMA, K
中科院分区：
文献类型：
--
作者：
HASHIMOTO, T;KODA, H;KURIYAMA, K
在重复施用 MAP（5 mg/kg，腹膜内注射 x 2/天，5 天）后，研究了小鼠（雄性 STD-ddy）对 d-甲基苯丙胺 (MAP) 的行为敏感性及其与大脑儿茶酚胺能系统神经化学变化的相关性。重新给予 MAP（0.625 mg/kg）后，经过 MAP 预处理的小鼠表现出 MAP 刺激的运动活动增强。在这些致敏小鼠中，大脑去甲肾上腺素（NE）和多巴胺（DA）的代谢周转率显着下降。而酪氨酸羟化酶、多巴脱羧酶、单胺氧化酶和儿茶酚-O-甲基转移酶的活性在相同的实验条件下没有表现出变化。另一方面，重复的MAP预处理诱导[3H]二氢阿普洛尔和[3H]螺哌酮与大脑突触膜的特异性结合增强，这是由于Bmax值增加所致。此外，用普萘洛尔（10 mg/kg）和氟哌啶醇（0.1 mg/kg）预处理小鼠可抑制 MAP 行为敏感性的发展。这些结果表明大脑β-肾上腺素能和多巴胺能受体的超敏感性可能与MAP的行为敏感有关。
Behavioral sensitization of mice (male STD-ddy) to d-methamphetamine (MAP) and its correlation with neurochemical alterations in cerebral catecholaminergic systems were investigated following the repeated administration of MAP (5 mg/kg, i.p. .times. 2/day, 5 days). MAP-pretreated mice showed an enhancement in MAP-stimulated locomotor activity following the readministration of MAP (0.625 mg/kg). The metabolic turnovers of cerebral norepinephrine (NE) and dopamine (DA) showed a significant decrease in these sensitized mice. The activities of tyrosine hydroxylase, DOPA decarboxylase, monoamine oxidase and catechol-O-methyltransferase, however, showed no change under the same experimental conditions. On the other hand, the repeated MAP pretreatment induced the enhancement of the specific bindings of [3H]dihydroalprenolol and [3H]spiperone to cerebral synaptic membrane, which resulted from the increase of Bmax values. Furthermore, pretreatments of mice with propranolol (10 mg/kg) and haloperidol (0.1 mg/kg) inhibited the development of behavioral sensitization to MAP. These results suggest that the supersensitivity in cerebral .beta.-adrenergic and dopaminergic receptor may be involved in behavioral sensitization to MAP.