MORTYN JONES MEMORIAL LECTURE
MORTYN JONES MEMORIAL LECTURE
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莫廷·琼斯纪念讲座
DOI：
10.1111/j.1365-2826.1993.tb00476.x
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发表时间：
1993
影响因子：
3.2
通讯作者：
M. Parker
中科院分区：
文献类型：
--
作者：
M. Parker
雌激素通过调节特定的基因活性来影响靶细胞的许多发育和生理反应。它们的作用是由一种可溶性的细胞内受体介导的，该受体的功能是配体依赖的转录因子(I，2)。除了它们刺激或抑制特定基因转录速率的主要作用外，它们还可能调节转录后事件和其他非基因组事件。在Mortyn Jones的第四次演讲中，我描述了我们在雌激素受体(ER)的结构和功能方面的工作，特别是与雌二醇的作用和抗雌激素阻断雌激素作用的机制有关的工作。内质网是转录因子超家族的一员，其活性依赖于激素配体的结合。与核激素受体家族的其他成员一样，ER从反应基因附近的位置起作用，称为反应元件，具有转录增强子(1，3)的特性。核激素受体有两个共同的特征，即含有锌指基序的DNA结合区和负责配体结合的疏水性C末端区域(3，4)。蛋白质家族目前大约50个，不仅包括类固醇激素受体，还包括甲状腺激素和维甲酸受体以及许多其他被称为孤儿受体的受体，其配体尚未确定(5)。
Oestrogens influence many developmental and physiological responses in target cells by regulating specific gene activity. Their action is mediated by a soluble intracellular receptor that functions as a ligand-dependent transcription factor (I, 2). In addition to their primary role to stimulate or repress rates of specific gene transcription they may also regulate post-transcriptional events and other non-genomic events. In the fourth Mortyn Jones lecture I describe our work on the structure and function of the oestrogen receptor (ER), particularly as it relates to the role of oestradiol and the mechanism by which antioestrogens block oestrogen action. The ER is a member of a large superfamily of transcription factors whose activity depends on the binding of a hormonal ligand. In common with other members of the nuclear hormone receptor family the ER functions from sites in the vicinity of responsive genes, termed response elements, with the properties of transcriptional enhancers (1, 3). Nuclear hormone receptors share two characteristic features, namely a DNA binding domain containing a zinc finger motif and a hydrophobic C-terminal region responsible for ligand binding (3, 4). The family of proteins, currently approximately fifty, includes not only the steroid hormone receptors but also the thyroid hormone and retinoic acid receptors and many others, referred to as orphan receptors, for which a ligand has not been identified (5).
行为和分子分析表明，黑腹果蝇的昼夜节律输出被断开的突变体破坏。
DOI：
10.1002/j.1460-2075.1992.tb05020.x
发表时间：
1992
期刊：
The EMBO journal
影响因子：
--
作者：
Hardin,PE;Hall,JC;Rosbash,M
通讯作者：
Rosbash,M
具有组成型转录活性的变异人乳腺肿瘤雌激素受体。
影响因子：
11.2
作者：
Fuqua,SA;Fitzgerald,SD;Chamness,GC;Tandon,AK;McDonnell,DP;Nawaz,Z;O'Malley,BW;McGuire,WL
通讯作者：
McGuire,WL
他莫昔芬对乳腺癌女性脊柱骨密度的影响。
DOI：
10.1093/jnci/81.14.1086
发表时间：
1989
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Turken,S;Siris,E;Seldin,D;Flaster,E;Hyman,G;Lindsay,R
通讯作者：
Lindsay,R