NY-ESO-1 expression in sarcomas A diagnostic marker and immunotherapy target
NY-ESO-1 expression in sarcomas A diagnostic marker and immunotherapy target
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DOI：
10.4161/onci.21059
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发表时间：
2012-11-01
期刊：
影响因子：
7.2
通讯作者：
Lee, Chyi-Chia R.
中科院分区：
文献类型：
--
作者：
Lai, Jin-Ping;Rosenberg, Avi Z.;Lee, Chyi-Chia R.
NY-ESO-1（CTAG 1B）在大多数滑膜肉瘤和粘液样/圆细胞脂肪肉瘤以及黑色素瘤的子集中高度表达，但在其他间叶肿瘤中很少表达。这表明使用NY-ESO-1对这些病变进行鉴别诊断的可能性。此外，在黑色素瘤和滑膜肉瘤患者亚群中测试NY-ESO-1靶向免疫疗法的临床试验中已经获得了有希望的结果。
NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.