Messages from the Mineral: How Bone Cells Communicate with Other Tissues.
Messages from the Mineral: How Bone Cells Communicate with Other Tissues.
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DOI：
10.1007/s00223-023-01091-2
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发表时间：
2023-07
影响因子：
4.2
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中科院分区：
文献类型：
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骨是一种高度动态的组织，骨形成和骨吸收细胞的持续作用负责达到峰值骨量，维持成年人的骨量，以及随后随着衰老和绝经而发生的骨丢失，以及疾病和药物副作用的骨骼并发症。目前公认，骨形成成骨细胞和骨吸收破骨细胞的产生和活性受到骨细胞（包埋在骨基质中的成骨细胞衍生的细胞）的调节。骨细胞之间的相互作用通过直接接触和分泌的分子发生。除了调节骨细胞功能外，这些细胞释放的分子也能够到达循环，并对健康个体的其他组织和器官产生影响。此外，骨细胞产物也与疾病的建立或进展有关，包括癌症和肌无力。在这篇综述中，我们将讨论骨作为内分泌器官的作用，以及所选的成骨细胞、骨细胞和破骨细胞分泌的分子对其他组织的影响。
Bone is a highly dynamic tissue, and the constant actions of bone-forming and bone-resorbing cells are responsible for attaining peak bone mass, maintaining bone mass in the adults, and the subsequent bone loss with aging and menopause, as well as skeletal complications of diseases and drug side-effects. It is now accepted that the generation and activity of bone-forming osteoblasts and bone-resorbing osteoclasts is modulated by osteocytes, osteoblast-derived cells embedded in the bone matrix. The interaction among bone cells occurs through direct contact and via secreted molecules. In addition to the regulation of bone cell function, molecules released by these cells are also able to reach the circulation and have effects in other tissues and organs in healthy individuals. Moreover, bone cell products have also been associated with the establishment or progression of diseases, including cancer and muscle weakness. In this review, we will discuss the role of bone as an endocrine organ, and the effect of selected, osteoblast-, osteocyte-, and osteoclast-secreted molecules on other tissues.