Association of primate T-cell lymphotropic virus infection of pig-tailed macaques with high mortality.
Association of primate T-cell lymphotropic virus infection of pig-tailed macaques with high mortality.
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猪尾猕猴灵长类 T 细胞嗜淋巴细胞病毒感染与高死亡率的关联。
DOI：
10.1006/viro.2002.1705
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发表时间：
2002
期刊：
影响因子：
3.7
通讯作者：
Fultz,PatriciaN
中科院分区：
文献类型：
--
作者：
McGinn,ThereseM;Tao,Binli;Cartner,Samuel;Schoeb,Trenton;Davis,Ian;Ratner,Lee;Fultz,PatriciaN
人类嗜T淋巴细胞病毒I型（HTLV-I）和旧世界非人灵长类动物与猿猴对应物STLV-I的自然感染与一小部分个体在长潜伏期后发生肿瘤性疾病有关。HTLV-I也是一种进展更快的神经系统疾病HTLV-I相关脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）的病原体。猕猴已被实验性地用于评估HTLV-I候选疫苗的有效性的研究中，但没有观察到疾病的证据。在这里，我们报告了实验感染的猪尾猕猴与STLV-I（SM）和HTLV-I（ACH），这两个都与疾病综合征的特点是快速发病，体温过低，嗜睡，并在数小时至数天内死亡。其他病理后遗症包括腹泻、皮疹、膀胱功能障碍、体重减轻，还有一只动物出现关节病。这两种逆转录病毒在一些动物的中枢神经系统中检测到，无论是通过培养或直接抗原捕获p19 Gag在脑脊液中。虽然病毒在整个感染过程中从外周血单核细胞（PBMC）中回收，但所有感染的猕猴均保持低抗病毒抗体滴度和稳定的前病毒负荷，通常在10至100拷贝/106 PBMC之间。然而，13只感染HTLV-I（ACH）或STLV-I（SM）的猕猴中，有7只动物（54%）在感染后35周至41 - 2年间死亡。在相对较短的时间内，这种意外的高死亡率表明，感染猪尾猕猴可能是一个有用的模型，用于研究免疫反应和HTLV-I感染引起的病理事件。
Natural infection of humans with human T-cell lymphotropic virus type I (HTLV-I) and of old world nonhuman primates with the simian counterpart, STLV-I, is associated with development of neoplastic disease in a small percentage of individuals after long latent periods. HTLV-I is also the etiologic agent of a more rapidly progressive neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Macaques have been used experimentally in studies to evaluate HTLV-I candidate vaccines for efficacy, but no evidence of disease was observed. Here we report experimental infection of pig-tailed macaques with STLV-I(sm) and HTLV-I(ACH), both of which were associated with a disease syndrome characterized by rapid onset, hypothermia, lethargy, and death within hours to days. Other pathologic sequelae included diarrhea, rash, bladder dysfunction, weight loss, and, in one animal, arthropathy. Both retroviruses were detected in the central nervous systems of some animals, either by culture or by direct antigen capture for p19 Gag in cerebrospinal fluid. Although virus was recovered throughout infection from peripheral blood mononuclear cells (PBMC), all infected macaques maintained low antiviral antibody titers and stable proviral burdens, which generally ranged between 10 and 100 copies per 106PBMC. However, of 13 macaques infected with HTLV-I(ACH) or STLV-I(sm), seven animals (54%) died between 35 weeks and 41 2 years after infection. This unexpected high mortality within a relatively short time suggests that infection of pig-tailed macaques might be a useful model for studying immune responses to and pathologic events resulting from HTLV-I infection.