Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction
Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction
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DOI：
10.1111/j.1471-0528.2006.00882.x
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发表时间：
2006-05-01
影响因子：
5.8
通讯作者：
Sibbons, PD
中科院分区：
文献类型：
--
作者：
Egbor, M;Ansari, T;Sibbons, PD
目的应用体视学技术评价妊娠合并早发型和晚发型先兆子痫（PET）伴或不伴胎儿生长受限（FGR）的胎盘形态学改变。20名妇女妊娠并发PET，17名FGR和16名PET和FUR;其余16名来自孕龄匹配的对照组。各组进一步分为早发组和对照组，（< 34周）和晚发（> 34周）基于胎龄。设置NPIMR在Northwick Park和St Marks医院。人群胎盘孕妇。方法福尔马林固定，蜡包埋切片用抗CD 34抗体染色，并用苏木精复染。主要结果测量胎盘厚度，表面积，长度，结果早发型PET病例中，终末绒毛体积和表面积受损，晚发型PET对外周绒毛和血管特征无影响。在中间和末端绒毛的血管和绒毛亚组分的形态显着影响迟发性FGR，而早发性FGR引起胎盘重量减少。长度估计不受PET，FGR或发病年龄的影响。中间小动脉形状因子显着降低迟发性FGR.Conclusions孤立早发性PET与异常胎盘形态，但晚发性PET胎盘形态相似，胎盘从孕龄匹配的对照，确认存在两个子集的这种情况，并支持这一假设，晚发性PET是一种母亲的疾病，而不是胎盘疾病。
Objective To evaluate placental morphology in pregnancies complicated by early- and late-onset pre-eclampsia (PET) with and without fetal growth restriction (FGR) using stereological techniques.Design A total of 69 pregnant women were studied. Twenty women had pregnancies complicated by PET, 17 by FGR and 16 by both PET and FUR; the remaining 16 were from gestational-age-matched controls. Each group was further classified into early onset (< 34 weeks) and late onsets (> 34 weeks) based on gestational ages.Setting NPIMR at Northwick Park and St Marks Hospital.Population placentae from pregnant women.Methods Formalin-fixed, wax-embedded sections stained with anti-CD34 antibodies and counterstained with haematoxylin.Main outcome measures Volumes, surface areas, lengths, diameters and shape factors of the villous tissues and fetal vasculature in the intermediate and terminal villi of all the groups studied.Results Terminal villi volume and surface area were compromised in early-onset PET cases, late-onset PET had no impact on peripheral villi or vasculature features. The morphology of the vascular and villous subcomponents in the intermediate and terminal villi was significantly influenced by late-onset FGR, whereas early-onset FGR caused a reduction in placental weight. Length estimates were not influenced by PET, FGR or age of onset. Intermediate arteriole shape factor was significantly reduced in late-onset FGR.Conclusions Isolated early-onset PET was associated with abnormal placental morphology, but placentas from late-onset PET were morphologically similar to placentas from gestational-age-matched controls, confirming the existence of two subsets of this condition and supporting the hypothesis that late-onset PET is a maternal disorder and not a placental disease.