REGULATION OF THE EXPRESSION OF THE RAT ANGIOTENSIN-II RECEPTOR MESSENGER-RNA
REGULATION OF THE EXPRESSION OF THE RAT ANGIOTENSIN-II RECEPTOR MESSENGER-RNA
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DOI：
10.1016/0006-291x(92)91844-g
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发表时间：
1992-02-14
影响因子：
3.1
通讯作者：
INAGAMI, T
中科院分区：
文献类型：
--
作者：
IWAI, N;INAGAMI, T
通过竞争性聚合酶链反应方法评估大鼠肾上腺、主动脉、肾脏和大脑中血管紧张素 II 受体 mRNA 表达水平的调节。双侧肾切除术或给予 Dup753 显着降低了肾上腺和脑干中该受体 mRNA 的表达水平，但肾脏和主动脉中的表达水平没有显着降低。连续输注血管紧张素 II 会增加肾上腺中该受体 mRNA 的表达水平，但其他组织中则不会。提示该受体mRNA在肾上腺中的表达水平依赖于肾素-血管紧张素-醛固酮系统。
Regulation of the expression levels of the rat angiotensin II receptor mRNA in the adrenal, aorta, kidney, and brain was assessed by the competitive polymerase chain reaction method. The bilateral nephrectomy or the administration of Dup753 markedly reduced the expression levels of this receptor mRNA in the adrenal and brain stem, but not in the kidney nor aorta. A continuous infusion of angiotensin II increased the expression level of this receptor mRNA in the adrenal but not in the other tissues. It is suggested that the expression level of this receptor mRNA in the adrenal is dependent on the renin angiotensin aldosterone system.