RETINOIC ACID AND HOMEOBOX GENE-REGULATION
RETINOIC ACID AND HOMEOBOX GENE-REGULATION
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DOI：
10.1016/0959-437x(94)90071-a
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发表时间：
1994-08-01
影响因子：
4
通讯作者：
GUDAS, LJ
中科院分区：
文献类型：
--
作者：
LANGSTON, AW;GUDAS, LJ
同源框基因已被证明是脊椎动物模式形成的重要调节因子。视黄酸已被证明在体外和体内都会影响同源框基因的表达，并且它对发育的一些影响与同源框基因表达的变化相对应。最近在同源框基因附近发现了视黄酸反应性增强子，这表明视黄酸不仅仅是一种强大的药理试剂，而且在形成同源框基因的正常表达模式中起着重要作用。
Hox genes have been shown to be important regulators of pattern formation in vertebrates, Retinoic acid has been shown to affect the expression of Hox genes in vitro and in vivo, and some of its effects on development correspond to changes in Hox gene expression. The idea that retinoic acid is not simply a powerful pharmocological agent, but rather that it plays an important role in creating the normal expression patterns of Hox genes, is provided by the recent identification of retinoic acid responsive enhancers near Hox genes.