Effect of physical activity on calcium and phosphorus metabolism in the rat.
Effect of physical activity on calcium and phosphorus metabolism in the rat.
复制标题
体力活动对大鼠钙磷代谢的影响。
DOI：
--
复制
发表时间：
1989
影响因子：
--
通讯作者：
S. Yasumura
中科院分区：
文献类型：
--
作者：
James K. Yeh;J. Aloia;S. Yasumura
在四组大鼠中研究了骨骼质量、营养钙和磷平衡以及肠道钙吸收的变化：对照组、允许自由获取食物的运动组、配对喂养至对照水平的运动组和固定组。运动方案包括跑台运动25 m/min，60 min/d，5 d/wk，共13 wk;大鼠双侧坐骨神经去支配制动。通过中子活化分析测量全身钙（TBCa）作为骨骼质量的指标。标准的代谢平衡技术被用来确定钙和磷平衡，并在原位十二指肠环结扎准备被用来研究主动和被动的肠道钙转运过程。运动促进了正的钙和磷平衡，增加了骨骼质量，主要是由于增加了1，25-二羟维生素D和肠道钙吸收效率的提高。尿中钙和磷的排泄量与对照水平没有差异，食物摄入量不是一个因素，因为成对喂养的大鼠对运动的反应几乎与随意喂养的大鼠相同。相反，固定导致TBCa减少和较低的Ca和P平衡。这些作用是尿矿物质排泄增加、内源性粪便排泄增加和肠道矿物质吸收效率降低的结果。
Changes in skeletal mass, nutritional calcium and phosphorus balance, and intestinal calcium absorption were studied in four groups of rats: control, exercise allowing free access to food, exercise with pair-feeding to control levels, and immobilization. The exercise regimen consisted of treadmill running 25 m/min, 60 min/day, 5 days/wk for 13 wk; rats were immobilized by bilateral sciatic denervation. The total body Ca (TBCa) was measured by neutron activation analysis as an index of skeletal mass. Standard metabolic balance techniques were used to determine calcium and phosphorus balance, and an in situ duodenal loop ligation preparation was used to study the active and passive intestinal Ca transport processes. Exercise promoted a positive Ca and P balance and increased the skeletal mass, largely as a result of an increase in 1,25-dihydroxyvitamin D and an enhancement of the intestinal Ca absorption efficiency. Urinary excretion of Ca and P did not differ from control levels and food intake was not a factor because pair-fed rats responded to exercise almost identically to those fed ad libitum. Conversely, immobilization caused a decrease in TBCa and a lower Ca and P balance. These effects are the result of an increased urinary mineral excretion, greater endogenous fecal excretion, and decreased mineral absorption efficiency in the intestine.
影响因子：
158.5
作者：
STEWART, AF;ADLER, M;BROADUS, AE
通讯作者：
BROADUS, AE