Nimodipine and acceleration of functional recovery of the facial nerve after crush injury.
Nimodipine and acceleration of functional recovery of the facial nerve after crush injury.
复制标题
尼莫地平与挤压伤后面神经功能恢复的加速作用。
DOI：
10.1001/archfacial.2009.95
复制
发表时间：
2010
影响因子：
--
通讯作者：
Hadlock,TessaA
中科院分区：
文献类型：
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作者：
Lindsay,RobinW;Heaton,JamesT;Edwards,Colin;Smitson,Christopher;Hadlock,TessaA
目的建立是否尼莫地平，钙通道阻滞剂，加速或以其他方式改善大鼠面神经挤压伤后搅拌的功能恢复。Methods 30只大鼠进行了暴露的左主干的面神经，然后由一个标准的挤压伤和随后的定量面部运动测试。将动物随机分为实验组（n = 15）和对照组（n = 15）。在面神经操作前4天，实验动物皮下植入尼莫地平分泌颗粒。所有动物在术前和术后第2、8 - 17、20、22、24和31天使用经验证的定量搅拌运动学装置进行测试。与对照组动物相比，接受尼莫地平治疗的动物在术后第5天（术后第9、11 ~ 13和20天）表现出明显更好的搅拌（分别为P<.001、P =.003、P =.009、P = .009和P = .009;单尾t检验）。总体而言，尼莫地平治疗的动物表现出较早的恢复与untreated animals.ConclusionsWe表明，尼莫地平提高恢复面神经粉碎后搅拌。这一发现证实了其他人的半定量研究结果，并提供了完整的搅拌运动学数据的影响。鉴于尼莫地平的不良反应较低，其对面神经损伤患者的给药可能具有临床意义。
ObjectiveTo establish whether nimodipine, a calcium channel blocker, accelerates or otherwise improves functional recovery of whisking after facial nerve crush injury in the rat.MethodsThirty rats underwent exposure of the left main trunk of the facial nerve followed by a standard crush injury and subsequent quantitative facial movement testing. Animals were randomized into an experimental group (n = 15) and a control group (n = 15). Four days prior to facial nerve manipulation, experimental animals underwent subcutaneous implantation of a nimodipine-secreting pellet. All animals were tested preoperatively and on postoperative days 2, 8 to 17, 20, 22, 24, and 31 using a validated, quantitative whisking kinematics apparatus. Whisks were analyzed for amplitude, velocity, and acceleration.ResultsAnimals receiving nimodipine demonstrated significantly better whisking on 5 days (postoperative days 9, 11 to 13, and 20) compared with control animals (P< .001,P= .003,P= .009,P= .009, andP= .009, respectively; 1-tailedttest). Overall, the nimodipine-treated animals showed earlier recovery compared with the untreated animals.ConclusionsWe demonstrate that nimodipine improves recovery of whisking after facial nerve crush. This finding corroborates the semiquantitative findings of others, and provides complete whisking kinematic data on its effects. Given the low adverse effect profile of nimodipine, there may be clinical implications in its administration in patients experiencing facial nerve injury.