Plasma insulin-like growth factor-1 level and risk of incident hypertension in nondiabetic women.
Plasma insulin-like growth factor-1 level and risk of incident hypertension in nondiabetic women.
复制标题
DOI：
10.1097/hjh.0b013e32834103bf
复制
发表时间：
2011-02
影响因子：
4.9
通讯作者：
Forman JP
中科院分区：
文献类型：
--
作者：
Zhang L;Curhan GC;Forman JP
Insulin-like growth factor-1 may be involved in regulation of blood pressure through multiple pathways; however, the prospective association between plasma insulin-like growth factor-1level and risk of hypertension has never been explored. We prospectively examined the association between plasma insulin-like growth factor-1 level and the risk of incident hypertension among 2046 women without a history of hypertension or diabetes. Cox proportional hazards regression models were used to adjust for potential confounders. We identified 181 incident cases of hypertension during 4-years of follow-up. After adjusting for plasma insulin-like growth factor binding protein-3 level and other potential confounders, women in the top tertile of insulin-like growth factor-1 had decreased risk of incident hypertension (relative risk 0.56, 95% confidence interval 0.35–0.91) compared with women in the bottom tertile. After further adjusting for C-peptide level and C-reactive protein level in subsets of participants who also had those markers measured, the association between insulin-like growth factor -1 and risk of incident hypertension remained robust. Higher circulating insulin-like growth factor-1 level is associated with a decreased risk of incident hypertension among non-diabetic women.
