TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress
TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress
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DOI：
10.1042/bst0370273
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发表时间：
2009-02-01
影响因子：
3.9
通讯作者：
Petersen, Janni
中科院分区：
文献类型：
--
作者：
Petersen, Janni
细胞生长和细胞分裂共同控制细胞的大小，这种协调通常受营养物质供应的调节。在许多真核生物中，TOR(雷帕霉素的靶标)信号参与了营养感知与细胞生长和分裂控制的耦合。营养胁迫会抑制TOR信号，从而提前细胞分裂的时间，从而导致细胞继续分裂，细胞尺寸缩小。环境中的大多数变化都会刺激压力激活的MAPK(丝裂原激活蛋白激酶)信号通路。一些MAPK也在有丝分裂的开始和细胞分裂的控制中起着普遍的作用。在这篇文章中，我讨论了两个主要的信号通路--TOR和压力MAPK信号通路在控制有丝分裂过程中的相互作用，主要集中在裂殖酵母(Schizosoccharmyces Pombe)。
Cell growth and cell division are coupled to control cell size and this co-ordination is often modulated by the availability of nutrients. In many eukaryotes, TOR (target of rapamycin) signalling is involved in coupling nutrient sensing to cell growth and division controls. Nutrient stress inhibits TOR signalling to advance the timing of cell division and thus leads to continued cell division at reduced cell size. Most changes in the environment stimulate stress-activated MAPK (mitogen-activated protein kinase) signalling pathways. Several MAPKs also have a general role in the control of mitotic onset and cell division. in the present paper, I discuss the interplay between two major signalling pathways, the TOR and the stress MAPK signalling pathways, in controlling mitotic commitment, with the main focus being on fission yeast (Schizosoccharomyces pombe).