Soluble α -Klotho Serum Levels in Chronic Kidney Disease.
Soluble α -Klotho Serum Levels in Chronic Kidney Disease.
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DOI：
10.1155/2015/872193
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发表时间：
2015
影响因子：
2.8
通讯作者：
Mazzaferro S
中科院分区：
文献类型：
--
作者：
Rotondi S;Pasquali M;Tartaglione L;Muci ML;Mandanici G;Leonangeli C;Sales S;Farcomeni A;Mazzaferro S
Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport. Decreased TM-Klotho, described in experimental chronic kidney disease (CKD), prevents actions of FGF23 and lessens circulating s-Klotho. Thus, levels of s-Klotho could represent a marker of CKD-MBD. To evaluate the clinical significance of s-Klotho in CKD we assayed serum s-Klotho and serum FGF23 in 68 patients (age 58 ± 15; eGFR 45 ± 21 mL/min). s-Klotho was lower than normal (519 ± 183 versus 845 ± 330 pg/mL, P < .0001) in renal patients and its reduction was detectable since CKD stage 2 (P < .01). s-Klotho correlated positively with eGFR and serum calcium (Cas) and negatively with serum phosphate (Ps), PTH and FGF23. FGF23 was higher than normal (73 ± 51 versus 36 ± 11, P < .0002) with significantly increased levels since CKD stage 2 (P < .001). Our data indicate a negative effect of renal disease on circulating s-Klotho starting very early in CKD. Assuming that s-Klotho mirrors TM-Klotho synthesis, low circulating s-Klotho seems to reflect the ensuing of tubular resistance to FGF23, which, accordingly, is increased. We endorse s-Klotho as an early marker of CKD-MBD.
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影响因子：
3.7
作者：
Kitagawa M;Sugiyama H;Morinaga H;Inoue T;Takiue K;Ogawa A;Yamanari T;Kikumoto Y;Uchida HA;Kitamura S;Maeshima Y;Nakamura K;Ito H;Makino H
通讯作者：
Makino H
影响因子：
3.7
作者：
Sakan H;Nakatani K;Asai O;Imura A;Tanaka T;Yoshimoto S;Iwamoto N;Kurumatani N;Iwano M;Nabeshima Y;Konishi N;Saito Y
通讯作者：
Saito Y
影响因子：
3.7
作者：
Nowak A;Friedrich B;Artunc F;Serra AL;Breidthardt T;Twerenbold R;Peter M;Mueller C
通讯作者：
Mueller C
DOI：
10.1006/bbrc.2000.4226
发表时间：
2001-02-02
影响因子：
3.1
作者：
Koh, N;Fujimori, T;Nabeshima, Y
通讯作者：
Nabeshima, Y
影响因子：
13.6
作者：
Olauson, Hannes;Lindberg, Karolina;Larsson, Tobias E.
通讯作者：
Larsson, Tobias E.