Zika Virus The Agent and Its Biology, With Relevance to Pathology
Zika Virus The Agent and Its Biology, With Relevance to Pathology
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DOI：
10.5858/arpa.2016-0409-ra
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发表时间：
2017-01-01
影响因子：
4.6
通讯作者：
Rothman, Alan L.
中科院分区：
文献类型：
--
作者：
Medin, Carey L.;Rothman, Alan L.
寨卡病毒（ZIKV）曾经默默无闻，但在过去一年中引起了医学和科学界的极大关注，因为最近将这种病毒引入西半球引起了大规模疫情。特别是，严重的先天性感染和格林-巴利综合征病例的发生使这种病毒直接进入临床和解剖病理学家的视野。这篇综述文章提供了ZIKV的基本介绍，它的遗传学，结构特征和生物学。多学科的努力将是必不可少的，以建立ZIKV的基本病毒学的临床病理学相关性，以促进诊断，治疗和疫苗的发展。
Once obscure, Zika virus (ZIKV) has attracted significant medical and scientific attention in the past year because of large outbreaks associated with the recent introduction of this virus into the Western hemisphere. In particular, the occurrence of severe congenital infections and cases of Guillain-Barre syndrome has placed this virus squarely in the eyes of clinical and anatomic pathologists. This review article provides a basic introduction to ZIKV, its genetics, its structural characteristics, and its biology. A multidisciplinary effort will be essential to establish clinicopathologic correlations of the basic virology of ZIKV in order to advance development of diagnostics, therapeutics, and vaccines.