Are Actinomyces viscosus antigens B cell mitogens?
Are Actinomyces viscosus antigens B cell mitogens?
复制标题
粘性放线菌抗原是 B 细胞有丝分裂原吗？
作者：
J. Burckhardt;B. Guggenheim;A. Hefti
粘性放线菌Ny 1的胞外杂多糖（ECHG）和超声处理的细胞上清液（SCS）诱导强烈的淋巴细胞增殖。这在无菌大鼠脾和胸导管细胞中得到证实，并在常规“裸”小鼠脾细胞中得到证实。脾细胞对密集偶联的TNP-SRBC产生直接空斑形成细胞。ECHG对大鼠脾淋巴细胞的促有丝分裂作用经弱碱性水解后明显减弱，对裸鼠脾细胞的促有丝分裂作用则完全消失。提示ECHG和SCS具有促B细胞有丝分裂作用。
An extracellular heteroglycan (ECHG) and a sonicated cell supernatant (SCS) of Actinomyces viscosus Ny 1 induced strong lymphocyte proliferation. This was shown with spleen and thoracic duct cells form germfree rats and confirmed with cells from conventional "nude" mouse spleens. Spleen cells developed direct plaque-forming cells against densely coupled TNP-SRBC. The mitogenic property of ECHG was diminished considerably after mild alkaline hydrolysis for lymphocytes form rat spleens and was totally abolished for cells from "nude" mouse spleens. These results suggest that ECHG and SCS have B cell mitogenicity.