Executive function tests in early-onset psychosis: which one to choose?
Executive function tests in early-onset psychosis: which one to choose?
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早发性精神病的执行功能测试：选择哪一项？
DOI：
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发表时间：
2012
影响因子：
2.1
通讯作者：
B. Rund
中科院分区：
文献类型：
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作者：
A. Holmén;M. Juuhl;R. Thormodsen;K. Sundet;I. Melle;B. Rund
精神分裂症患者表现出执行功能缺陷，这一领域在成人型精神分裂症(AOS)组中得到了很好的研究，但在早发性精神分裂症(EOS)中则要少得多。由于EOS总体上似乎表现出比AOS更差的认知功能，在临床上更容易受到损害，因此在两组中选择有效和敏感的评估方法并不一定相同。Matrics Consensus Cognitive Battery是在研究治疗效果时为成年人开发的，并使用迷宫(神经心理评估电池[NAB])来评估执行功能。我们对31名患有精神分裂症谱系障碍的青少年和66名健康对照进行了测试，以检查迷宫与其他两种常用的衡量执行功能的测试--D-KEFS颜色词干扰测试(Stroop)和威斯康星卡片分类测试(WCST)--的比较。对所有三个指标都发现了显著的区分能力。患者比对照组低0.8-1.5 SD，其中Stroop是最敏感的方法，其次是迷宫和WCST。Matrics选择了迷宫来评估AOS的治疗效果，并被证明是能够的。我们发现该仪器还能够将青少年患者与对照组分开，因此，它似乎是临床环境中一个明智的选择。如果需要对执行功能领域进行更详细的神经心理学评估，Stroop应该被认为是一种补充测试。
People with schizophrenia exhibit executive functioning deficits, an area well investigated in the adult onset schizophrenia (AOS) group, but far less so in early-onset schizophrenia (EOS). Since EOS in general seems to exhibit poorer cognitive functions and is clinically more compromised than AOS, choice of efficient and sensitive assessment measures is not necessarily the same within the two groups. The MATRICS Consensus Cognitive Battery was developed for adults when studying treatment effects and uses Mazes (Neuropsychological Assessment Battery [NAB]) to assess executive functioning. We tested 31 adolescents with schizophrenia spectrum disorders and 66 healthy controls in order to examine how Mazes compares to two other commonly used tests to measure executive functioning, D-KEFS Color Word Interference Test (Stroop) and the Wisconsin Card Sorting Test (WCST). Significant discriminating power was found for all three measures. Patients performed 0.8-1.5 SD below controls with Stroop as the most sensitive measure, followed by Mazes and WCST. Mazes was selected by the MATRICS to assess treatment effects in AOS and is shown to be able. We find the instrument also able to separate adolescent patients from controls and thus, it appears a sensible choice in clinical settings. If a more elaborated neuropsychological evaluation of the executive functioning domain is needed, Stroop should be considered a complementary test.
影响因子：
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作者：
Minzenberg, Michael J.;Laird, Angela R.;Thelen, Sarah;Carter, Cameron S.;Glahn, David C.
通讯作者：
Glahn, David C.
影响因子：
2.4
作者：
Koren, D;Seidman, LJ;Tsuang, MT
通讯作者：
Tsuang, MT