Effect of meaning on apraxic finger imitation deficits
Effect of meaning on apraxic finger imitation deficits
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DOI：
10.1016/j.neuropsychologia.2015.12.022
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发表时间：
2016-02-01
期刊：
影响因子：
2.6
通讯作者：
Weiss, P. H.
中科院分区：
文献类型：
--
作者：
Achilles, E. I. S.;Fink, G. R.;Weiss, P. H.
失用症通常由左半球（LH）引起，但也由右半球（RH）中风引起，并且经常损害手势模仿。特别是在LH卒中中，重要的是要区分失用症引起的手势模仿缺陷与那些由于共病失语症和相关的语义缺陷，可能会影响有意义的（MF）手势的模仿。为了探讨这个问题，我们首先调查了广泛使用的手指模仿测试中的10个所谓无意义（ML）手势是否真的没有意义，或者测试是否也包含MF手势，要求健康受试者（n=45）将这些手势归类为MF或ML。大多数健康受试者（98%）将10个手势中的3个归类为明显的MF。只有两个手势被认为是主要ML。我们接下来评估了如何模仿中风患者（255 LH，113 RH中风）的手势意义的影响，以及如何失语症影响模仿LH中风患者（n=208）。所有患者，特别是模仿缺陷患者（LH 17%，RH中风患者27%）模仿MF手势明显优于ML手势。重要的是，所有10个手势的意义分数显着预测模仿缺陷患者的模仿分数。此外，特别是在LH中风患者的模仿缺陷，失语症的严重程度显着影响模仿MF，但ML gesteres.Our的研究结果在一个大型患者队列支持目前的认知模型的模仿，并强烈建议ML手势是特别敏感的检测模仿缺陷，同时尽量减少混淆影响失语症的MF手势的模仿LH中风患者。(C)2015爱思唯尔有限公司版权所有。
Apraxia typically results from left-hemispheric (LH), but also from right-hemispheric (RH) stroke, and often impairs gesture imitation. Especially in LH stroke, it is important to differentiate apraxia-induced gesture imitation deficits from those due to co-morbid aphasia and associated semantic deficits, possibly influencing the imitation of meaningful (MF) gestures. To explore this issue, we first investigated if the 10 supposedly meaningless (ML) gestures of a widely used finger imitation test really carry no meaning, or if the test also contains MF gestures, by asking healthy subjects (n=45) to classify these gestures as MF or ML. Most healthy subjects (98%) classified three of the 10 gestures as clearly MF. Only two gestures were considered predominantly ML.We next assessed how imitation in stroke patients (255 LH, 113 RH stroke) is influenced by gesture meaning and how aphasia influences imitation of LH stroke patients (n=208). All patients and especially patients with imitation deficits (17% of LH, 27% of RH stroke patients) imitated MF gestures significantly better than ML gestures. Importantly, meaningfulness-scores of all 10 gestures significantly predicted imitation scores of patients with imitation deficits. Furthermore, especially in LH stroke patients with imitation deficits, the severity of aphasia significantly influenced the imitation of MF, but not ML gestures.Our findings in a large patient cohort support current cognitive models of imitation and strongly suggest that ML gestures are particularly sensitive to detect imitation deficits while minimising confounding effects of aphasia which affect the imitation of MF gestures in LH stroke patients. (C) 2015 Elsevier Ltd. All rights reserved.