Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospital
Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospital
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DOI：
10.1016/j.transci.2012.07.014
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发表时间：
2012-12-01
影响因子：
1.9
通讯作者：
Hagag, Adel A.
中科院分区：
文献类型：
--
作者：
Aly, Rabab;El-sharnoby, Mohamed R.;Hagag, Adel A.
前言：镰状细胞性贫血(SCA)是埃及坦塔市的一个重要公共卫生问题。红细胞输注可能会降低SCA的发病率，但它们也有许多风险。在其他风险类别中，对红细胞抗原的同种免疫可能是由于输血造成的。本研究的目的是探讨定期输血的SCA患者中红细胞同种异体抗体的发生率。材料和方法：共42例SCA患者。这项工作计划利用身份证微分型系统研究不同红细胞抗原的同种异体抗体在多次输血的SCA患者中的存在。收集和分析临床和实验室资料，了解多次输血后红细胞免疫继发的频率、模式和影响因素。结果：42例SCA患者中，21.4%的患者出现同种异体抗体。最常见的同种异体抗体是抗K、抗E和抗C。同种异体抗体的发生率分别为7.1%、4.8%和4.8%。同种异体抗体与输血率显著相关。接受和未接受同种异体免疫的患者的平均年龄分别为12.0岁和6.2岁。结论：输血SCA患者中常见的是临床意义不同的次要红细胞抗原的同种异体免疫。定期筛查红细胞同种异体抗体将为这些患者提供更好的管理。(C)2012爱思唯尔有限公司。保留所有权利。
Introduction: Sickle cell anemia (SCA) is an important public health issue in Tanta, Egypt. Erythrocyte transfusions may reduce the morbidity of SCA, however, they are associated with numerous risks. Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The objective of this study was to explore the frequency of red cell alloantibodies among SCA patients who received regular transfusions.Materials and methods: A total of 42 patients with SCA were included in this study. This work planned to study the presence of alloantibodies to different red cell antigens in multi-transfused SCA patients using the ID card micro-typing system. Clinical and laboratory data were collected and analyzed to find out the frequency, pattern and factors influencing red cell alloimmunization secondary to multiple blood transfusion in these patients.Results: Of a total of 42 SCA patients included in the study, 21.4% of patients developed alloantibodies. The most common alloantibodies were anti-K, anti-E and anti-C. The rate of incidence of these alloantibodies was 7.1%, 4.8% and 4.8%, respectively. There was significant association between alloantibody and the rate of transfused blood. The mean age of patients with and without alloimmunization was 12.0 and 6.2 years.Conclusions: Alloimmunization to minor erythrocyte antigens of variable clinical significance is a frequent finding in transfused SCA patients. Regular screening for red cell alloantibodies would provide better management of these patients. (C) 2012 Elsevier Ltd. All rights reserved.