Exophiala spinifera as a cause of cutaneous phaeohyphomycosis: case study and review of the literature.
Exophiala spinifera as a cause of cutaneous phaeohyphomycosis: case study and review of the literature.
复制标题
Exophiala spinifera 作为皮肤暗色丝孢菌病的原因：案例研究和文献综述。
DOI：
10.1080/13693780802412611
复制
发表时间：
2009
期刊：
影响因子：
2.9
通讯作者：
Kovarik,Carrie
中科院分区：
文献类型：
--
作者：
Harris,JohnE;Sutton,DeannaA;Rubin,Adam;Wickes,Brian;DeHoog,GS;Kovarik,Carrie
外盾壳菌作为皮肤病的病原体在文献中报道了18次。皮肤病变的临床表现多种多样，包括丘疹、疣状斑块和深皮下肿块。疾病的临床分布和病程也是可变的，取决于患者的年龄和免疫能力。组织学表现为两种模式之一-暗色丝孢菌病或着色芽生菌病。WhileE. spinifera似乎是敏感的多种抗菌药物在体外，临床经验与治疗方式一直是可变的。在测序方法可用之前，种属鉴定是基于组织中的组织病理学表现和培养物中真菌的形态学特征。很可能是E。由于早期方法的不正确鉴定，棘皮病急性感染被低估。我们报告一个额外的情况E。spiniferaphaeohyphomycosis，第一个被明确确定的测序。此外，我们总结了可变的临床，组织病理学和形态学特征，以及治疗反应所描述的皮肤感染引起的E。刺果。
Exophialaspiniferahas been reported as an agent of cutaneous disease 18 times in the literature. Clinical presentations of cutaneous lesions vary widely, including erythematous papules, verrucous plaques, and deep subcutaneous abscesses. The clinical distribution and course of disease are also variable, depending on the age and immune competency of the patient. Histologic appearance occurs in one of two patterns — phaeohyphomycosis or chromoblastomycosis. WhileE. spiniferaappears to be susceptible to multiple antimicrobial agentsin vitro, clinical experience with treatment modalities has been variable. Prior to the availability of sequencing methods, species identification was based on the histopathologic presentation in tissue and morphologic features of the fungus in culture. It is likely thatE. spiniferacutaneous infections have been underreported due to its incorrect identification based on earlier methods. We report an additional case ofE. spiniferaphaeohyphomycosis, the first to be definitively identified by sequencing. In addition, we summarize the variable clinical, histopathologic, and morphologic features, as well as treatment responses described in previously reported cutaneous infections caused byE. spinifera.