B lymphocytes as emerging mediators of insulin resistance.
B lymphocytes as emerging mediators of insulin resistance.
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DOI：
10.1038/ijosup.2012.2
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发表时间：
2012-07
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肥胖与包括内脏脂肪组织（VAT）在内的各种组织的慢性炎症相关，这有助于胰岛素抵抗。T细胞和巨噬细胞浸润肥胖症中的VAT并协调这种炎症。最近，我们有了一个令人惊讶的发现，即B细胞是这一过程的重要贡献者。因此，一些B细胞和它们产生的抗体可以促进VAT相关的全身性炎症，导致胰岛素抵抗。本报告将重点介绍这些B细胞的特性，以及它们如何通过T细胞调节和致病性自身抗体的产生来促进胰岛素抵抗。了解B细胞导致胰岛素抵抗的机制将导致新的基于抗体的诊断和B细胞调节疗法来管理这种日益流行的疾病。
Obesity is associated with chronic inflammation of various tissues including visceral adipose tissue (VAT), which contributes to insulin resistance. T cells and macrophages infiltrate VAT in obesity and orchestrate this inflammation. Recently, we made the surprising discovery that B cells are important contributors to this process. Thus, some B cells and the antibodies they produce can promote VAT-associated and systemic inflammation, leading to insulin resistance. This report will focus on the properties of these B cells, and how they contribute to insulin resistance through T-cell modulation and production of pathogenic autoantibodies. Understanding the mechanisms by which B cells contribute to insulin resistance should lead to new antibody-based diagnostics and B-cell modulating therapeutics to manage this increasingly prevalent disease.