Efficacy of cocktail phage therapy in treating Vibrio cholerae infection in rabbit model
Efficacy of cocktail phage therapy in treating Vibrio cholerae infection in rabbit model
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DOI：
10.1016/j.micinf.2012.11.002
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发表时间：
2013-02-01
影响因子：
5.8
通讯作者：
Sarkar, Banwarilal
中科院分区：
文献类型：
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作者：
Jaiswal, Abhishek;Koley, Hemanta;Sarkar, Banwarilal
在兔模型中检测了五种裂解性噬菌体的混合物对抗霍乱弧菌O1感染的能力。在一组中，在给予V霍乱弧菌O1之前6和12小时，给予兔1 × 10（8）噬菌斑形成单位的噬菌体混合物，而在另一组中，在感染后6和12小时应用相同的程序。观察到在口服细菌攻击后口服给予噬菌体混合物显著降低了细菌的脱落（p < 0.01）。相反，在细菌攻击之前的噬菌体处理没有这种效果（p > 0.05）。结果表明，口服噬菌体后，V霍乱的挑战，可以提供一种可能的手段，打击V霍乱感染。(C)2012巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Ability of a cocktail of five lytic vibriophages to combatting Vibrio cholerae O1 infection in rabbit model was examined. In one group, rabbits were administered 1 x 10(8) plaque forming unit of phage cocktail 6 and 12 h prior to the administration of V cholerae O1, while in the other group, same procedure was applied 6 and 12 h post infection. It was observed that oral administration of the phage cocktail after oral bacterial challenge lowered the shedding of bacteria significantly (p < 0.01). In contrast phage treatment prior to bacterial challenge had no such effect (p > 0.05). Results suggest that oral administration of phage subsequent to V cholerae challenge could provide a possible means of combatting V cholerae infection. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.