L-β-(5-Hydroxy-2-pyridyl)-alanine and L-β-(3-Hydroxyureido)-alanine from Streptomyces
L-β-(5-Hydroxy-2-pyridyl)-alanine and L-β-(3-Hydroxyureido)-alanine from Streptomyces
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来自链霉菌的 L-β-(5-羟基-2-吡啶基)-丙氨酸和 L-β-(3-羟基脲基)-丙氨酸
DOI：
10.1248/cpb.23.2669
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发表时间：
1975
影响因子：
1.7
通讯作者：
T. Niida
中科院分区：
文献类型：
--
作者：
S. Inouye;T. Shomura;T. Tsuruoka;Y. Ogawa;Hiroshi Watanabe;J. Yoshida;T. Niida
在对放线菌代谢产物进行化学筛选的过程中，分离到两种不常见的氨基酸：L-β-（5-羟基-2-吡啶基）-丙氨酸（1）和L-β-（3-羟基脲基）-丙氨酸（9）。从这些氨基酸及其衍生物的理化性质阐明了1和9的结构，并通过合成得到支持。化合物1及其甲酯（2）的抗菌活性可被L-酪氨酸拮抗，化合物9及其衍生物（17）的抗菌活性可被L-谷氨酰胺拮抗。
In the course of the chemical screening study on the metabolites from actinomycetes, two unusual amino acids were isolated : L-β-(5-Hydroxy-2-pyridyl)-alanine (1) and L-β-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester (2) were antagonized by L-tyrosine, and those of 9 and its derivative (17) by L-glutamine.