Cardiovascular Events and Intensity of Treatment in Polycythemia Vera
Cardiovascular Events and Intensity of Treatment in Polycythemia Vera
复制标题
DOI：
10.1056/nejmoa1208500
复制
发表时间：
2013-01-03
影响因子：
158.5
通讯作者：
Barbui, Tiziano
中科院分区：
文献类型：
--
作者：
Marchioli, Roberto;Finazzi, Guido;Barbui, Tiziano
背景目前对真性红细胞增多症患者的治疗建议是维持红细胞压积低于45%，但这种治疗策略尚未在随机临床试验中进行过测试。方法我们随机分配了365名JAK 2阳性真性红细胞增多症成人，他们正在接受静脉切开术、羟基脲或两者兼而有之的治疗，接受更强化的治疗（目标红细胞压积，
BACKGROUNDCurrent treatment recommendations for patients with polycythemia vera call for maintaining a hematocrit of less than 45%, but this therapeutic strategy has not been tested in a randomized clinical trial.METHODSWe randomly assigned 365 adults with JAK2-positive polycythemia vera who were being treated with phlebotomy, hydroxyurea, or both to receive either more intensive treatment (target hematocrit,