Homeobox Genes Exhibit Evolutionary Conserved Regionalization in the Central Nervous System of an Ascidian Larva
Homeobox Genes Exhibit Evolutionary Conserved Regionalization in the Central Nervous System of an Ascidian Larva
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海鞘幼虫中枢神经系统中的同源盒基因表现出进化保守的区域化
DOI：
10.2108/zsj.13.479
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发表时间：
1996
影响因子：
6.1
通讯作者：
H. Saiga
中科院分区：
文献类型：
--
作者：
Y. Katsuyama;S. Wada;H. Saiga
摘要脊索动物门各亚组动物都有一个相似的过程，即形成管状中枢神经系统。然而，对脊索动物、脊椎动物、头索动物和尾索动物（被囊动物）的中枢神经系统之间的空间关系知之甚少。海鞘是尾索动物亚门的一个主要动物类群。在本研究中，我们研究了唇和正齿相关基因的海鞘，Halocynthia roretzi，在发育中的幼虫中枢神经系统的表达模式。这些同源异型盒基因表现出区域特异性的表达模式，是惊人的相似的小鼠Hoxb-1和Otx 2。区域化的特点是这些基因的表达支持以前的形态学研究所建议的海鞘幼虫中枢神经系统的部门。此外，保守的同源异型盒基因的表达模式表明，这种区域化发生在中枢神经系统的一个假定的共同祖先的脊索动物。
Abstract Animals in each subgroup of the phylum Chordata exhibit a similar process by which they form a tubular central nervous system (CNS). However, little is known about spatial relationship among the CNSs of chordates; vertebrates, cephalochordates and urochordates (tunicates). Ascidians constitute a major animal group in the subphylum Urochordata. In the present study, we examined the expression patterns of labial and orthodenticle related genes of the ascidian, Halocynthia roretzi, in the developing larval CNS. These homeobox genes exhibited region-specific expression patterns that are strikingly similar to those of murine Hoxb-1 and Otx2. The regionalization as characterized by the expression of these genes supports the division of the ascidian larval CNS suggested by the previous morphological studies. Furthermore, conservation of the expression pattern of the homeobox genes suggests that such regionalization occurred in the CNS of a putative common ancestor of chordates.
影响因子：
4.6
作者：
M. A. Frohman;Monica Boyle;Gail R. Martin
通讯作者：
M. A. Frohman;Monica Boyle;Gail R. Martin