Myeloid cells in cancer-related inflammation
Myeloid cells in cancer-related inflammation
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DOI：
10.1016/j.imbio.2014.10.001
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发表时间：
2015-02-01
期刊：
影响因子：
2.8
通讯作者：
Bonecchi, Raffaella
中科院分区：
文献类型：
--
作者：
Caronni, Nicoletta;Savino, Benedetta;Bonecchi, Raffaella
髓样细胞是癌症相关炎症的关键因素，具有不仅支持肿瘤生长而且支持侵袭和转移的潜力。肿瘤衍生因子影响骨髓细胞分化，诱导支持肿瘤生长的表型，诱导免疫抑制，血管生成和组织重塑。在原发性肿瘤部位产生的可溶性介质也可以以远程模式起作用，诱导骨髓细胞从骨髓中释放，所述骨髓细胞在肿瘤引流淋巴器官中具有免疫抑制活性，并且当迁移到转移性器官时可以倾向于定植。在这里，我们将审查目前的知识的贡献，肿瘤衍生的信号，影响骨髓细胞的极化激活，骨髓释放和招聘到转移部位，特别关注趋化因子的作用。(C)2014 Elsevier GmbH. All rights reserved.
Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines. (C) 2014 Elsevier GmbH. All rights reserved.