Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp.
Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp.
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来自夏威夷真菌分离物的生物活性天然产物：来自Phalemoniopsis sp.的次生代谢物。
DOI：
10.1080/21501203.2014.931309
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gloer,JamesB
中科院分区：
文献类型：
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作者：
Kaur,Amninder;Rogers,KristinaD;Swenson,DaleE;Dowd,PatrickF;Wicklow,DonaldT;Gloer,JamesB
本文描述了两种真菌分离物的化学研究，这两种真菌分离物最初被鉴定为瓶霉属的成员.这两个分离物都是作为在夏威夷岛上收集的其他真菌的殖民者获得的，后来被指定为P。弯曲的然而，P. curvatum最近被重新分类为一个新属（Phialemoniopsis）的成员，并更名为Phialemoniopsis curvata。对这些分离株之一的固体基质发酵培养物的研究提供了oxirapentyn类似物和destruxin A4作为主要成分，而对第二种菌株的分析导致分离出几种简单的芳香代谢物和一种称为gabusectin的混合生物起源的化合物，该化合物以前仅在专利中报道过。主要通过详细的核磁共振和质谱分析来分配结构，并且通过X射线晶体学来确认两个主要组分的结构。本报告构成的第一个描述的次生代谢产物的成员Phialemoniopsis。
Chemical investigations of two fungal isolates initially identified as members of the genusPhialemoniumare described. Both isolates were obtained as colonists of other fungi collected on the island of Hawaii and were later assigned asP. curvatum. However,P. curvatumhas recently been reclassified as a member of a new genus (Phialemoniopsis) and renamed asPhialemoniopsis curvata. Studies of solid–substrate fermentation cultures of one of these isolates afforded an oxirapentyn analogue and destruxin A4as major components, while analysis of the second strain led to the isolation of several simple aromatic metabolites and a compound of mixed biogenetic origin called gabusectin that had previously been reported only in a patent. Structures were assigned mainly by detailed nuclear magnetic resonance and mass spectrometry analysis, and those of two of the major components were confirmed by X-ray crystallography. This report constitutes the first description of secondary metabolites from a member of the genusPhialemoniopsis.