Leukaemia inhibitory factor in serum and follicular fluid of women with polycystic ovary syndrome and its correlation with IVF outcome
Leukaemia inhibitory factor in serum and follicular fluid of women with polycystic ovary syndrome and its correlation with IVF outcome
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DOI：
10.1016/j.rbmo.2017.12.020
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发表时间：
2018-04-01
影响因子：
4
通讯作者：
Li, Weiping
中科院分区：
文献类型：
--
作者：
Li, Zewu;Zhu, Yueting;Li, Weiping
多囊卵巢综合征(PCOS)以高雄激素血症、卵巢功能障碍和多囊卵巢形态为特征。白血病抑制因子(LIF)影响许多生殖活动，包括卵泡发育、胚胎植入和生长。本研究的目的是探讨多囊卵巢综合征(PCOS)患者血清和卵泡液中LIF水平，并与接受体外受精-胚胎移植(IVF-ET)的对照组进行比较。PCOS患者血清和卵泡液中LIF浓度均低于对照组。PCOS患者卵泡液中雌二醇水平高于对照组。多囊卵巢综合征组血清(r=0.6263，P<0.05)和卵泡液(r=0.7093，P<0.05)LIF水平与雌二醇水平呈负相关。在PCOS组和对照组中，卵泡液中的LIF浓度在怀孕的妇女和没有怀孕的妇女之间没有差异。然而，在多囊卵巢综合征联合组和对照组中，体外受精后怀孕的女性胚胎培养液中的LIF浓度高于未怀孕的女性。提示血清和卵泡液中低浓度的LIF可能是PCOS卵泡发生障碍的原因之一。胚胎培养液中LiF浓度可预测IVF治疗的结局。(C)2018年生殖健康有限公司。爱思唯尔有限公司出版。保留所有权利。
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Leukaemia inhibitory factor (LIF) affects many reproductive activities, including follicular development, embryo implantation and growth. The aim of this study was to evaluate LIF concentrations in serum and follicular fluid of women with PCOS and controls who underwent IVF with embryo transfer (IVF-ET). Serum and follicular fluid LIF concentrations were lower in women with PCOS compared with controls. Oestradiol concentrations in follicular fluid were higher in PCOS subjects compared with controls. LIF concentrations in serum (r = 0.6263, P < 0.05) and follicular fluid (r = 0.7093, P < 0.05) were negatively correlated with oestradiol concentration in the PCOS group. LIF concentrations in follicular fluid showed no difference between women who conceived and women who did not in both PCOS and control groups. However, LIF concentrations in embryo culture medium were higher in women who conceived following IVF compared with women who did not, in combined PCOS and control groups. The findings indicate that low LIF concentrations in serum and follicular fluid may contribute to disordered folliculogenesis in PCOS. LIF concentrations in embryo culture medium may predict the outcome of IVF treatment. (c) 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.