Progenitor cells in acute lung injury.
Progenitor cells in acute lung injury.
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DOI：
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发表时间：
2006-06
影响因子：
3.2
通讯作者：
Ellen L. Burnham;Marc Moss
中科院分区：
文献类型：
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作者：
Ellen L. Burnham;Marc Moss
目的急性肺损伤（acute lung injury，ALI）和急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS）是常见的严重肺部疾病，发病率和死亡率高。改善这些疾病结局的特定疗法尚未出现。人们越来越有兴趣探索新的疗法，即干细胞，以修复在这些疾病中观察到的肺损伤。在这份手稿中，干细胞研究在肺医学领域的划定，重点是内皮祖细胞（EPCs）在急性肺损伤的设置。方法回顾了该领域的相关文献，包括最近的动物模型研究。与评估内皮祖细胞在移植后的人类受试者和肺炎患者的工作进行了描述。详细介绍了ALI患者循环EPCs的测定。结果ALI患者循环中EPCs的数量较健康对照组增加。此外，在校正年龄、性别和疾病严重程度评分的影响的多变量分析中，更多数量的循环EPC与改善的结局相关。结论EPCs代表了重症监护医学中迅速扩大的兴趣。然而，它们的具体性质和效用方面的肺损伤需要进一步划定之前，他们在治疗急性肺损伤的使用。
AIM Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common and serious pulmonary illnesses associated with a high morbidity and mortality. A specific therapy that improves outcomes in these disorders has not been forthcoming. There is growing interest to explore novel therapies, namely stem cells, to repair damage to the lung that is observed in these disorders. In this manuscript, stem cell investigations in the field of pulmonary medicine are delineated, with a focus on endothelial progenitor cells (EPCs) in the setting of ALI. METHODS A review of the pertinent literature in this field is presented, including recent investigations in animal models. Work related to the assessment of EPCs in human subjects after transplantation and in patients with pneumonia is described. The measurement of circulating EPCs in those with ALI is presented in detail. RESULTS Patients with ALI have an increased number of circulating EPCs than do healthy controls. Further, a greater number of circulating EPCs is associated with improved outcomes in a multivariable analysis correcting for the effects of age, gender, and severity of illness scores. CONCLUSIONS EPCs represent a rapidly expanding interest in critical care medicine. However, their specific properties and utilities with regards to lung injury need to be further delineated prior to their use in the therapy of ALI.