Albuminuria predicting outcome in diabetes: Incidence of microalbuminuria in Asia-Pacific Rim
Albuminuria predicting outcome in diabetes: Incidence of microalbuminuria in Asia-Pacific Rim
复制标题
DOI：
10.1111/j.1523-1755.2004.09209.x
复制
发表时间：
2004-11-01
影响因子：
19.6
通讯作者：
Weir, MR
中科院分区：
文献类型：
--
作者：
Weir, MR
微量白蛋白尿在普通人群中并不罕见，即使在没有糖尿病、高血压或心血管危险因素的人群中也是如此。美国的流行病学研究，如NHANES III，报告了22244例有或无糖尿病患者的微量白蛋白尿总发病率为7.8%。在糖尿病患者中，患病率为28.8%。即使在没有糖尿病、心血管疾病或血清肌酐水平异常的患者中，微量白蛋白尿的患病率仍为5.1%。同样，荷兰的一项有41,000名参与者的大型研究表明，微量白蛋白尿的发病率为7%。在这些糖尿病患者中，微量白蛋白尿率为16%。因此，在美国和欧洲，患病率研究表明微量白蛋白尿并不罕见。在东南亚和西太平洋，2型糖尿病的发病率正在迅速上升。预计到2025年，全球2型糖尿病的主要流行地区将不是北美或欧洲，而是亚太地区。因此，评估该地区微量白蛋白尿的发生率是很有意义的。在微量白蛋白尿患病率研究（MAPS）中，来自10个亚洲国家的6800名成年高血压糖尿病患者的大量白蛋白尿患病率为18.8%，微量白蛋白尿患病率为39.8%。因此，有重要证据表明，微量白蛋白尿和大量白蛋白尿在太平洋地区的大量流行表明糖尿病心血管和肾脏疾病即将大流行。
Microalbuminuria is not an unusual finding in the general population, even in individuals without diabetes, hypertension, or cardiovascular risk factors. Prevalence studies in the United States, such as NHANES III, reported an overall incidence of microalbuminuria in 22,244 patients, with and without diabetes, of 7.8%. In those individuals with diabetes, the prevalence was 28.8%. Even in patients without diabetes, cardiovascular disease, or abnormal serum creatinine levels, the prevalence of microalbuminuria was still 5.1%. Similarly, a large Dutch study of 41,000 participants demonstrated a 7% incidence of microalbuminuria. In those individuals with diabetes, the microalbuminuria rate was 16%. Thus, in both the United States and Europe, prevalence studies indicate that microalbuminuria is not uncommon.In southeast Asia and the western Pacific, the incidence of type 2 diabetes is rapidly escalating. It is expected that by 2025 the major prevalence of type 2 diabetes in the world will not be in North America or Europe but in Asia-Pacific Rim. Consequently, there is great interest in evaluating the incidence of microalbuminuria in this region. In the Microalbuminuria Prevalence Study (MAPS) the prevalence of macroalbumin-uria was noted to be 18.8% and microalbuminuria 39.8% in a total of 6800 hypertensive diabetic adult patients from 10 Asian countries.Thus, there is important evidence that the substantial prevalence of microalbuminuria and macroalbuminuria in the Pacific region indicates an impending pandemic of diabetic cardiovascular and renal disease.