Clinical applications of gene therapy in head and neck cancer.
Clinical applications of gene therapy in head and neck cancer.
复制标题
基因治疗在头颈癌中的临床应用。
作者：
M. Karamouzis;A. Argiris;J. Grandis
尽管在手术、放疗和将新型全身性药物纳入治疗方面取得了进展，但头颈部癌患者的长期结局仍不令人满意。对头颈部癌症生物学的日益了解表明，靶向控制癌发生或肿瘤进展的分子事件可能为头颈部癌症提供新的治疗方法。头颈部鳞状细胞癌（SCCHN）的特点是局部扩散，临床上是可行的，使其成为一个有吸引力的目标，肿瘤内基因治疗，一个潜在的有效的实验治疗。基因治疗的全身递送也是可能的，尽管有几个限制。在这篇综述中，我们将讨论SCCHN癌症基因治疗的基本原理，递送方法和积累的临床数据。
Despite advances in surgery, radiotherapy, and the incorporation of novel systemic agents into treatment, long-term outcomes of patients with head and neck cancer remain unsatisfactory. The growing understanding of head and neck cancer biology suggests that targeting molecular events governing carcinogenesis or tumor progression may provide novel therapeutic approaches for head and neck cancer. Squamous cell carcinoma of the head and neck (SCCHN) is characterized by locoregional spread and is clinically accessible, making it an attractive target for intratumoral gene therapy, a potentially efficacious experimental treatment. Systemic delivery of gene therapy may be also possible, albeit with several limitations. In this review we will discuss the rationale, delivery methods, and accumulated clinical data with cancer gene therapy in SCCHN.