Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption
Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption
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DOI：
10.1016/j.ajodo.2009.05.029
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发表时间：
2011-02-01
影响因子：
3
通讯作者：
Yoshida, Noriaki
中科院分区：
文献类型：
--
作者：
Gonzales, Carmen;Hotokezaka, Hitoshi;Yoshida, Noriaki
简介：尽管氟化物对牙釉质和根龋的有益作用已被充分证明，但关于氟化物对牙釉质引起的根吸收和牙齿移动的影响的数据有限。我们的目的是研究从出生到12周全身给予氟对药物诱导的大鼠磨牙牙根吸收和牙齿移动的影响。方法：雄性Wistar大鼠50只，随机分为5组。阴性对照组不给予氟化钠，牙齿不移动。阳性对照组不给予氟化钠，但有牙齿移动。三个实验组分别从出生到第2、4和12周接受45 ppm的氟化钠。在第10周，将50 g镍钛螺旋弹簧应用于上颌左第一磨牙2周。在12周龄时处死大鼠。在数字化X线头影测量片上测量上颌第一磨牙相对于上颌第二磨牙的移动。用扫描电镜和三维激光显微镜观察近、远中牙根。结果：氟降低了实验组骨吸收坑的深度、体积和粗糙度。然而，该面积与阳性对照组相似。关于氟化物摄入的持续时间，通过饮用水给予氟化物的时间越长，观察到的牙齿移动量越小。结论：出生后饮用含氟水可降低牙根吸收的严重程度，但牙齿移动量也减少。(Am J Orthod Dentofacial Orthop 2011;139：196-205）
Introduction: Even though the beneficial effects of fluoride on enamel and root caries have been well documented, limited data are available concerning the effect of fluoride on orthodontically induced root resorption and tooth movement. Our objective was to investigate the effect of systemic fluoride administered from birth to 12 weeks on orthodontically induced root resorption and tooth movement in rat molars. Methods: Fifty male Wistar rats were randomly divided into 5 groups. The negative control group received no sodium fluoride and had no tooth movement. The positive control group received no sodium fluoride but had tooth movement. Three experimental groups received sodium fluoride at 45 ppm from birth to 2, 4, and 12 weeks, respectively. At week 10, a 50-g nickel-titanium coil spring was applied to the maxillary left first molar for 2 weeks. The rats were killed at 12 weeks of age. Movement of the maxillary first molars was measured in relation to the maxillary second molar on digitized cephalometric radiographs. Mesial and distal roots were examined by using scanning electron and 3-dimensional laser microscopes. Results: Fluoride reduced the depth, volume, and roughness of the resorption craters in the experimental groups. However, the area was similar to that in the positive control group. Regarding the duration of fluoride intake, the longer fluoride was administered via drinking water, the smaller the amount of tooth movement observed. Conclusions: Fluoride in drinking water from birth reduced the severity of orthodontically induced root resorption, but the amount of tooth movement was also decreased. (Am J Orthod Dentofacial Orthop 2011;139:196-205)