LOSS OF ABDOMINAL FAT AND METABOLIC RESPONSE TO EXERCISE TRAINING IN OBESE WOMEN
LOSS OF ABDOMINAL FAT AND METABOLIC RESPONSE TO EXERCISE TRAINING IN OBESE WOMEN
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DOI：
10.1152/ajpendo.1991.261.2.e159
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发表时间：
1991-08-01
影响因子：
--
通讯作者：
BOUCHARD, C
中科院分区：
文献类型：
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作者：
DESPRES, JP;POULIOT, MC;BOUCHARD, C
许多研究表明，腹部脂肪的高度积累与代谢并发症和冠心病风险增加有关。 本研究调查了13名年龄为38.8 ± 5.3（SD）岁的肥胖绝经前妇女的体脂和腹部脂肪水平变化对代谢变量的影响。 妇女在大约55%的最大有氧功率（VO 2 max）下锻炼90分钟，每周4至5次，为期14个月。 训练后最大摄氧量显著增加，体脂量平均减少4.6 kg（P < 0.01），而去脂体重无变化。 通过计算机断层扫描测量的脂肪组织面积表明，腹部脂肪的损失大于大腿中部脂肪组织（P < 0.05）。 在口服葡萄糖耐量试验中测得的胰岛素生成指数以及血浆胆固醇（Chol）、低密度脂蛋白（LDL）-Chol和载脂蛋白（apo）B水平也显著降低（P < 0.05）。 运动还能显著升高血浆高密度脂蛋白（HDL）-apo A-I和HDL_2-Chol水平，降低血浆HDL_3-Chol水平（P < 0.05）。 运动后血浆脂蛋白脂酶活性无明显变化，而血浆肝甘油三酯脂酶活性明显降低（P < 0.005）。 代谢反应与最大摄氧量的变化无关，但与体脂量的减少和/或腹部深层脂肪的减少显著相关。 本研究的结果表明，全身脂肪和腹部脂肪水平的变化是更重要的相关性有氧运动训练引起的碳水化合物和脂质代谢的变化比心肺适应性的变化。
Numerous studies have shown that a high accumulation of abdominal fat is associated with metabolic complications and with an increased risk of coronary heart disease. The present study examined the effects of changes in body fatness and in the level of abdominal fat on metabolic variables in a sample of 13 obese premenopausal women, aged 38.8 +/- 5.3 (SD) yr. Women exercised for 90 min at approximately 55% of maximal aerobic power (VO2max) four to five times a week for a period of 14 mo. The training program induced a significant increase in VO2max and a mean reduction in body fat mass of 4.6 kg (P < 0.01), with no change in fat-free mass. Measurement of adipose tissue areas by computed tomography indicated a greater loss of abdominal fat compared with midthigh adipose tissue (P < 0.05). The training program also produced significant reductions in the insulinogenic index measured during an oral glucose tolerance test and in plasma cholesterol (Chol), low-density lipoprotein (LDL)-Chol, and apolipoprotein (apo) B levels (P < 0.05). Training also significantly increased plasma high-density lipoprotein (HDL)-apo A-I and HDL2-Chol levels and decreased plasma HDL3-Chol concentration (P < 0.05). Whereas no change in postheparin plasma lipoprotein lipase activity was noted, a significant decrease in postheparin plasma hepatic triglyceride lipase activity was observed after training (P < 0.005). Metabolic responses were not correlated with changes in VO2max but were significantly correlated with the reduction in body fat mass and/or with the loss of deep abdominal fat. Results of the present study suggest that changes in total body fat and in the level of abdominal fat are more important correlates of aerobic exercise training-induced changes in carbohydrate and lipid metabolism than changes in cardiorespiratory fitness.