Functions of the HIV-1 matrix protein p17.
Functions of the HIV-1 matrix protein p17.
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发表时间：
2006
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影响因子：
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通讯作者：
S. Fiorentini;E. Marini;S. Caracciolo;A. Caruso
中科院分区：
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作者：
S. Fiorentini;E. Marini;S. Caracciolo;A. Caruso
HIV-1复制是一个受病毒和宿主因素共同影响的动态过程。 HIV-1 基质蛋白 p17 是一种结构蛋白，在逆转录病毒生命周期的大部分阶段中发挥着重要作用。它参与病毒复制的早期阶段以及RNA靶向质膜、包膜掺入病毒粒子和颗粒组装的过程。除了其成熟的功能外，p17 还可以作为一种病毒细胞因子，在与细胞受体 (p17R) 结合后，作用于预激活的人类 T 细胞（但不作用于静止状态），促进增殖、促炎细胞因子释放和 HIV-1 复制。因此，p17可能在宿主和病毒衍生的刺激因子的复杂网络中发挥关键作用，有助于为HIV-1感染和复制创造有利的环境。在这里，我们简要概述了基质蛋白 p17 在 HIV-1 生命周期中发挥的功能，并总结了目前对 p17 如何促进 HIV-1 疾病发病机制的理解。
HIV-1 replication is a dynamic process influenced by a combination of viral and host factors. The HIV-1 matrix protein p17 is a structural protein critically involved in most stages of the life cycle of the retrovirus. It participates in the early stages of virus replication as well as in RNA targeting to the plasma membrane, incorporation of the envelope into virions and particle assembly. Besides its well established functions, p17 acts as a viral cytokine that works on preactivated--but not on resting--human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication after binding to a cellular receptor (p17R). Thus, p17 might play a key role in the complex network of host- and virus-derived stimulatory factors contributing to create a favourable environment for HIV-1 infection and replication. Here, we present a brief overview of the functions played by the matrix protein p17 in the HIV-1 life cycle and summarize the current understanding of how p17 could contribute to the pathogenesis of HIV-1 disease.