Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma
Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma
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DOI：
10.1097/00043764-200107000-00012
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发表时间：
2001-07-01
影响因子：
3.2
通讯作者：
Blair, A
中科院分区：
文献类型：
--
作者：
Zheng, TZ;Zahm, SH;Blair, A
最近的流行病学研究表明，农民使用氨基甲酸酯类杀虫剂会增加非霍奇金淋巴瘤（NHL）的风险。为了进一步探讨可能的关系，我们对在美国中西部四个州进行的三项基于人群的病例对照研究进行了汇总分析。本分析共纳入985例白色男性受试者和2895例对照受试者。非条件Logistic回归用于估计相关性和混杂控制。与非农民相比，曾经使用过氨基甲酸酯农药的农民患NHL的风险增加了30%到50%，而没有使用氨基甲酸酯农药的农民没有显示出风险增加。对单个氨基甲酸酯农药的分析发现，与西维因（而不是克百威、丁酸酯或S-乙基二丙基硫代氨基甲酸酯加保护剂）的关联更一致，在使用Satin的农民中，NHL的风险仅限于亲自处理产品的人，在疾病诊断前首次使用产品大于或等于20年的人，以及使用产品较长时间的人。在调整了其他主要类别的杀虫剂后，这些关联仍然存在。这些结果表明，与氨基甲酸酯农药使用相关的NHL风险增加，特别是西文。对该协会的进一步调查是必要的。
Recent epidemiological studies have suggested an increased risk of non-Hodgkin lymphoma (NHL)Srs m carbamate insecticide use among farmers. To further explore the possible relationships, we conducted a pooled analysis of three population-based case-control studies conducted in four midwestern states in the United States. A total of 985 white male subjects and 2895 control subjects were included in this analysis. Unconditional logistic regression was used to estimate the association and control for confounding. Compared with nonfarmers, farmers who had ever used carbamate pesticides had a 30 % to 50% increased risk of NHL, whereas farmers without carbamate pesticide use showed no increased risk. Analyses for individual carbamate pesticides found a more consistent association with Sevin but not carbofuran, butylate, or S-ethyl dipropylthiocarbamate plus protectant, Among farmers using Satin, the risk of NHL was limited to those who personally handled the product, those who first used the product for greater than or equal to 20 years before their disease diagnosis, and those who used the product for a longer period. These associations persisted after adjusting for other major classes of pesticides. These results suggest an increased risk of NHL associated with carbamate pesticide use, particularly Sevin. Further investigation of the association is warranted.