The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood.
The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood.
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额度额：从童年到成年期的扩散张量成像表征和发育变化。
DOI：
10.1002/hbm.22989
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发表时间：
2015-12
影响因子：
4.8
通讯作者：
Szeszko PR
中科院分区：
文献类型：
--
作者：
Karlsgodt KH;John M;Ikuta T;Rigoard P;Peters BD;Derosse P;Malhotra AK;Szeszko PR
眶额皮质和腹侧纹状体之间存在着解剖学上的联系，形成了一个所谓的奖励网络，这种联系在不同物种之间都得到了很好的建立。这种联系对奖赏处理有重要意义，并与许多神经精神疾病有关。此外，白色物质（WM）在青春期和成年早期会继续成熟，奖励网络的发展变化是决策和冒险模型的重要组成部分。尽管这种联系的重要性，潜在的WM最近才在人类组织学上得到表征，而尚未在体内使用脑成像。在这里，我们在295名8-68岁健康个体的大截面样本中实施了弥散张量成像（DTI），以进一步表征这种连接的WM及其从儿童到成年的发展。我们证明，额前束，连接眶额皮质和神经核，可以确定使用标准的DTI序列。使用泊松模型，我们发现，额前束经历了显着的变化，整个寿命，男性显示出更高和更早的峰值相比，女性。此外，这种变化发生的模式与决策的发展模式一致。这些研究结果支持了这一假设，即WM完整性的发展差异可能是一个促成因素，观察到的冒险发生在青春期。额前束尚未包括在标准的WM地图集，但可能是重要的，包括在研究调查额-纹状体网络，以及在调查药物滥用和决策。
The presence of an anatomical connection between the orbitofrontal cortex and ventral striatum, forming a so-called reward network, is well established across species. This connection has important implications for reward processing and is relevant to a number of neuropsychiatric disorders. Moreover, white matter (WM) is known to continue to mature across adolescence and into early adulthood, and developmental change in the reward network is an important component of models of decision making and risk taking. Despite the importance of this connection, the underlying WM has only recently been characterized in humans histologically, and not yet in-vivo using brain imaging. Here, we implemented diffusion tensor imaging (DTI) in a large cross-sectional sample of 295 healthy individuals ages 8–68 to further characterize the WM of this connection and its development from childhood into adulthood. We demonstrate that the accumbofrontal tract, connecting the orbitofrontal cortex and nucleus accumbens, can be identified using standard DTI sequences. Using Poisson modeling, we show that the accumbofrontal tract undergoes significant change across the lifespan, with males showing a higher and earlier peak compared to females. Moreover, the change occurs in a pattern consistent with developmental models of decision-making. These findings support the hypothesis that developmental differences in WM integrity may be a contributing factor to the observed risk taking that occurs in adolescence. The accumbofrontal tract is not yet included in standard WM atlases, but may be important for inclusion in studies investigating fronto-striatal networks, as well as in investigations of substance abuse and decision making.