Lewis Acid Catalyzed [3+2] Annulation of -Butyrolactone Fused Cyclopropane with Aldehydes/Ketones
Lewis Acid Catalyzed [3+2] Annulation of -Butyrolactone Fused Cyclopropane with Aldehydes/Ketones
复制标题
路易斯酸催化 [3 2] 丁内酯稠环丙烷与醛/酮的环化
DOI：
10.1002/ejoc.201800695
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发表时间：
2018
影响因子：
2.8
通讯作者：
Chai Zhuo
中科院分区：
文献类型：
--
作者：
Yang Pengfei;Shen Yue;Feng Manli;Yang Gaosheng;Chai Zhuo
本文报道了γ-丁内酯稠环丙烷在路易斯酸催化下与醛、酮的[3+2]环化反应。与其母体供体-受体(D-A)环丙烷相比，稠合双环环丙烷在这类环化过程中表现出更好的反应活性，提供了在温和的反应条件下获得具有多个相邻立体生成中心的密集取代γ-丁内酯稠合四氢呋喃的途径，催化剂负载量低(1-5mol%)，非对映选择性好，底物范围宽。
The [3+2] annulation reaction of γ‐butyrolactone fused cyclopropanes with aldehydes or ketones under Lewis acid catalysis is described. Compared to their parent donor–acceptor (D–A) cyclopropanes, such fused bicyclic cyclopropanes demonstrated much better reactivity in this type of annulation process, providing accesses to densely substituted γ‐butyrolactone fused tetrahydrofurans bearing multiple adjacent stereogenic centers with a low catalyst loading (1–5 mol‐%), excellent diastereoselectivity, and a broad substrate scope under mild reaction conditions.