Twenty-four hour recordings of colonic motility in patients with diverticular disease
Twenty-four hour recordings of colonic motility in patients with diverticular disease
复制标题
憩室病患者结肠运动的二十四小时记录
DOI：
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发表时间：
2001
影响因子：
3.9
通讯作者：
M. Tonini
中科院分区：
文献类型：
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作者：
G. Bassotti;E. Battaglia;F. Spinozzi;M. A. Pelli;M. Tonini
引言：结肠憩室病是西方国家最常见的病理实体之一。虽然大肠运动的改变通常被认为是主要的病理生理机制之一，但尚未有令人信服的证据。事实上，文献中只有少数关于远端结肠动力的相互矛盾的研究（没有关于有力推进活动的信息）。目得：本研究的目的是调查基础和刺激（餐后）结肠运动的横结肠（未受影响），降结肠和乙状结肠憩室疾病患者，连同高振幅传播收缩（质量运动）的检测。将患者的运动数据与健康对照受试者的运动数据进行比较。方法：10例患者和16例对照受试者，男女均招募了研究。在所有受试者中，通过结肠镜定位的测压导管记录结肠动力24小时。研究期间提供两份1000千卡的混合餐。研究结果：与对照组相比，憩室病患者的受累节段的运动量显著增加;患者组对生理刺激（进餐）的反应也异常。与对照组相比，憩室病患者的强力推进活动也显著增加（患者的平均值为10.3±2.7/受试者/天，对照组为5.5±0.8/受试者/天;P=0.051）;有趣的是，大约20%的这种活动是异常的，以逆行方式传播。结论：我们的结论是，结肠憩室病患者有异常的运动和推进活动的大肠，这是局限于受影响的部分。
INTRODUCTION: Diverticular disease of the colon is one of the most common pathologic entities in western countries. Although altered motility of the large bowel is commonly believed to be one of the major pathophysiologic mechanisms, no convincing evidence has been reported yet. In fact, only a few conflicting studies concerning distal colonic motility (with no information on forceful propulsive activity) are available in the literature. PURPOSE: The purpose of the present study was to investigate basal and stimulated (postprandial) colonic motility from the transverse (not affected), descending, and sigmoid colon in patients with diverticular disease, together with detection of high-amplitude propagated contractions (mass movements). Motility data from patients were compared with those obtained in healthy control subjects. METHODS: Ten patients and 16 control subjects of both sexes were recruited for the study. In all subjects, colonic motility was recorded for a 24-hour period by a colonoscopically positioned manometric catheter. Two 1000-kcal mixed meals were served during the study. RESULTS: Compared with control subjects, patients with diverticular disease displayed significantly increased amounts of motility in the affected segments; the response to a physiologic stimulus (meal) was also abnormal in the patients' group. Diverticular disease patients also had a significant increase of forceful propulsive activity compared with control subjects (average = 10.3±2.7/subject/day high-amplitude propagated contractions for patients and 5.5±0.8/subject/day for control subjects;P=0.051); interestingly, about 20 percent of such activity was abnormal, being propagated in a retrograde fashion. CONCLUSIONS: We concluded that patients with diverticular disease of the colon have abnormal motor and propulsive activities of the large bowel, which are confined to the affected segments.
肠易激综合征患者结肠运动的生理相关性。
影响因子：
1.3
作者：
Bassotti,G;Crowell,MD;Cheskin,LJ;Chami,TN;Schuster,MM;Whitehead,WE
通讯作者：
Whitehead,WE