A tripodal peptide ligand for asymmetric Rh(II) catalysis highlights unique features of on-bead catalyst development
A tripodal peptide ligand for asymmetric Rh(II) catalysis highlights unique features of on-bead catalyst development
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用于不对称 Rh(II) 催化的三足肽配体凸显了珠上催化剂开发的独特特征
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Z. Ball
中科院分区：
文献类型：
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作者：
Ramya Sambasivan;Wenwei Zheng;S. Burya;Brian V. Popp;C. Turro;C. Clementi;Z. Ball
通过高通量珠上筛选发现的用于铑（II）络合物的三齿eq-eq-ax肽配体是用于不对称环丙烷化反应的有效且选择性的催化剂。金属肽催化剂易于制备并在珠粒上筛选。轴向咪唑配体显著改善了催化剂功能，优于先前的单肽Rh（II）催化剂。实验和理论研究揭示了咪唑配体的作用和咪唑连接的结构后果。这些研究还解释了这些金属肽催化剂在溶液中和珠上的差异行为，并提供了一般的固定化均相催化剂的发展洞察。
A tridentate eq-eq-ax peptide ligand for rhodium(II) complexes, discovered by high-throughput on-bead screening, is an efficient and selective catalyst for asymmetric cyclopropanation reactions. The metallopeptide catalyst is easily prepared and screened on bead. The axial imidazole ligand significantly improves catalyst function over previous mono-peptide Rh(II) catalysts. Experimental and theoretical investigations shed light on the role of the imidazole ligand and the structural consequences of imidazole ligation. These studies also explain the differential behavior of these metallopeptide catalysts in solution and on bead, and provide insight into the development of immobilized homogeneous catalysts in general.
影响因子：
15
作者：
Hong, Soon Hyeok;Wenzel, Anna G.;Grubbs, Robert H.
通讯作者：
Grubbs, Robert H.
影响因子：
16.6
作者：
Gois, Pedro M. P.;Trindade, Alexandre F.;Cloke, F. Geoffrey N.
通讯作者：
Cloke, F. Geoffrey N.